除了关节处的磨损之外。
Beyond wear and tear at the joint.
作者信息
Liu Chuan-Ju
机构信息
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA.
出版信息
Science. 2025 Apr 4;388(6742):30-31. doi: 10.1126/science.adw4656. Epub 2025 Apr 3.
Abstract
Bile acid metabolism meets glucagon-like peptide 1 signaling in osteoarthritis.
摘要
胆汁酸代谢与骨关节炎中的胰高血糖素样肽-1信号通路相互作用。
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本文引用的文献
1
Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling.通过GLP-1介导的肠-关节轴治疗骨关节炎的靶点是肠道FXR信号通路。
Science. 2025 Apr 4;388(6742):eadt0548. doi: 10.1126/science.adt0548.
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Axial spondyloarthritis.中轴型脊柱关节炎
Lancet. 2025 Jan 11;405(10473):159-172. doi: 10.1016/S0140-6736(24)02263-3.
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Osteoarthritis.骨关节炎
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Glucagon-Like Peptide-1 Receptor Agonists and Osteoarthritis.
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Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis.每周一次司美格鲁肽治疗肥胖合并膝关节骨关节炎患者的疗效
N Engl J Med. 2024 Oct 31;391(17):1573-1583. doi: 10.1056/NEJMoa2403664.
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Ion channels in osteoarthritis: emerging roles and potential targets.骨关节炎中的离子通道：新兴作用和潜在靶点。
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