Liepa V E, Vol'pe E A, Mergina G R, Minchenok N Z, Bass-Shadkhan Kh F
Eksp Onkol. 1985;7(3):43-7.
Zymosan and its combinations with cyclophosphamide were tested for their effect on various immune responses. Zymosan alone had only minor effect on the cytotoxicity of lymphocytes to allogeneic and syngeneic tumour cells but significantly stimulated delayed-type hypersensitivity response, rosette formation and plaque forming cell response to sheep red blood cells in normal mice. Zymosan diminished immunosuppressive action of cyclophosphamide on the plaque and rosette formations and nonspecific allogeneic lysis of target cells by lymph node lymphocytes. Delayed-type hypersensitivity skin reaction and syngeneic T-killer cell activity increased significantly after the procedure of combination therapy. Lymphocyte stimulation action by the polysaccharide depended on the injection schedule used. Preliminary injection of zymosan was an optimal condition for enhancement of the cellular immune response.
对酵母聚糖及其与环磷酰胺的组合进行了测试，以观察它们对各种免疫反应的影响。单独使用酵母聚糖对淋巴细胞对同种异体和同基因肿瘤细胞的细胞毒性只有轻微影响，但能显著刺激正常小鼠的迟发型超敏反应、玫瑰花结形成以及对绵羊红细胞的空斑形成细胞反应。酵母聚糖减弱了环磷酰胺对空斑和玫瑰花结形成以及淋巴结淋巴细胞对靶细胞的非特异性同种异体裂解的免疫抑制作用。联合治疗后，迟发型超敏皮肤反应和同基因T杀伤细胞活性显著增加。多糖对淋巴细胞的刺激作用取决于所采用的注射方案。预先注射酵母聚糖是增强细胞免疫反应的最佳条件。
