Wang Chenxu, Liu Yunyun, Wan Jie-Ping
Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.
Org Lett. 2025 Apr 18;27(15):3983-3987. doi: 10.1021/acs.orglett.5c00946. Epub 2025 Apr 3.
A new synthetic method for the synthesis of bicyclic scaffolds featuring a dihydropyran and tetrahydrofuran (THF) hybrid in the fashion of a fused structure with excellent -selectivity is realized via the reactions of enaminones and THF. In addition to displaying a dual role as both a cyclic fragment and a one-carbon synthon, the current method also shows a rarely known mode of two vicinal C-H bonds' functionalization in THF or analogous oxa-heterocycles.
通过烯胺酮与四氢呋喃（THF）的反应，实现了一种合成双环骨架的新方法，该双环骨架具有二氢吡喃和四氢呋喃（THF）的稠合结构，具有优异的选择性。除了作为环状片段和一碳合成子发挥双重作用外，该方法还展示了一种鲜为人知的在四氢呋喃或类似的含氧杂环中两个相邻碳氢键官能团化的模式。
