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I-二甲基亚砜介导的多组分串联环化反应构建吡唑并[3,4-b]吡咯并[3,4-b]吡啶-6-酮骨架。

I-DMSO mediated multi-component cascade cyclization to construct pyrazolo[3,4-]pyrrolo[3,4-]pyridine-6-one skeleton.

作者信息

Song Yu-Man, Wang Li-Sheng, Zhou You, Tang Yong-Xing, Wu Chun-Yan, Wu Yan-Dong, Wu An-Xin

机构信息

State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University Wuhan Hubei 430079 China

State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou China.

出版信息

RSC Adv. 2025 Aug 8;15(34):28280-28284. doi: 10.1039/d5ra04871k. eCollection 2025 Aug 1.

DOI:10.1039/d5ra04871k
PMID:40861295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12376774/
Abstract

A one-pot synthesis of the pyrazolo[3,4-]pyrrolo[3,4-]pyridin-6-one skeleton has been developed using aryl methyl ketones, 3-aminopyrazoles, and enaminamides as substrates. This method features metal-free catalysis and broad substrate compatibility (36 examples). The reaction involves the formation of two C-C and two C-N bonds, while constructing a tetrasubstituted carbon stereocenter bearing a reactive hydroxyl group.

摘要

已开发出一种以芳基甲基酮、3-氨基吡唑和烯胺酰胺为底物一锅法合成吡唑并[3,4-b]吡咯并[3,4-b]吡啶-6-酮骨架的方法。该方法具有无金属催化和广泛的底物兼容性（36个实例）的特点。该反应涉及形成两个C-C键和两个C-N键，同时构建一个带有活性羟基的四取代碳立体中心。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/0fd2b64e7d5e/d5ra04871k-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/54a939a0899a/d5ra04871k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/558f406ee07b/d5ra04871k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/ed22a237ae71/d5ra04871k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/f5afb9c8bc1b/d5ra04871k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/c06b87c8361a/d5ra04871k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/0fd2b64e7d5e/d5ra04871k-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/54a939a0899a/d5ra04871k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/558f406ee07b/d5ra04871k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/ed22a237ae71/d5ra04871k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/f5afb9c8bc1b/d5ra04871k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/c06b87c8361a/d5ra04871k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f22/12376774/0fd2b64e7d5e/d5ra04871k-s5.jpg

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本文引用的文献

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用于选择性吲哚和苯并呋喃合成的α-烷氧基或α-羟基苯胺与烯胺酮的电化学环化反应
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