[核酸钠中钙双链RNA的抗肿瘤活性]
[Antitumor activity of Ca-double-stranded RNA from sodium nucleinate].
作者信息
Zakharian R A, Mespropian N P, Movsesian A V, Agabalian A S, Akopian Zh I
出版信息
Eksp Onkol. 1985;7(3):54-6.
PMID:4017933
Abstract
Ca-dsRNA introduced in the concentration of 5 micrograms per mouse 24 hours before the MG22a mouse hepatoma transplantation causes the 70% inhibition of the hepatoma growth. The sodium nucleinate used in the considerably higher concentration had a less effect. The sodium form of dsRNA also had a less antitumour effect comparing with its calcium form. The calcium form of dsRNA proves to be relatively stable and physiologically active form of dsRNA during its parenteral administration.
摘要
在MG22a小鼠肝癌移植前24小时，以每只小鼠5微克的浓度引入的钙双链RNA可导致肝癌生长受到70%的抑制。以相当高浓度使用的核酸钠效果较差。与钙形式相比，双链RNA的钠形式也具有较小的抗肿瘤作用。双链RNA的钙形式在其肠胃外给药过程中被证明是相对稳定且具有生理活性的双链RNA形式。
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