Salakaia R G, Amirian N B
Antibiotiki. 1984 Jul;29(7):507-9.
Possible prevention of the nephrotoxic effect of different doses of aminoglycoside antibiotics, such as monomycin, kanamycin and gentamicin was studied experimentally on chinchilla rabbits. Substances increasing the cell resistance (sodium nucleinate, prodigiosan and pyrogenal alone and sodium nucleinate combinations with the bacterial polysaccharides) were used. It was shown that sodium nucleinate prevented nephrotoxicity of the aminoglycosides in the doses 2.5 times higher than the therapeutic ones. The combined use of sodium nucleinate with pyrogenal or prodigiosan was most effective. It prevented the nephrotoxic effect of the antibiotics in the doses 5 times higher than the therapeutic ones.
在实验中，研究了不同剂量的氨基糖苷类抗生素（如单霉素、卡那霉素和庆大霉素）对龙猫兔的肾毒性作用的可能预防措施。使用了增强细胞抵抗力的物质（单独使用的核酸钠、灵菌红素和热原质以及核酸钠与细菌多糖的组合）。结果表明，核酸钠可预防比治疗剂量高2.5倍的氨基糖苷类药物的肾毒性。核酸钠与热原质或灵菌红素联合使用最为有效。它可预防比治疗剂量高5倍的抗生素的肾毒性作用。
