Hurley Laura P, Kurlandsky Kate, Breslin Kristin, Stein Amy, Hambidge Simon J, Shoup Jo Ann, Reifler Liza M, Daley Matthew F, Lewin Bruno, Goddard Kristin, Henninger Michelle L, Nelson Jennifer C, Vazquez-Benitez Gabriela, Hanson Kayla E, Fuller Candace C, Williams Joshua T B
Ambulatory Care Services, Denver Health and Hospitals, Denver, CO, USA.
Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Hum Vaccin Immunother. 2025 Dec;21(1):2467548. doi: 10.1080/21645515.2025.2467548. Epub 2025 Apr 3.
COVID-19 vaccination rates are decreasing despite vaccination being the most effective tool against severe disease from COVID-19. From October 1, 2022, to February 1, 2023, we conducted a cross-sectional study among adults in the Vaccine Safety Datalink about attitudes and beliefs regarding bivalent COVID-19 Omicron booster vaccine (hereafter referred to as COVID-19 bivalent vaccine) stratifying by vaccination status and race and ethnicity. Analysis was weighted for response and selection bias. The response rate was 27% (385/1430); 33% [95% CI: 21%-44%] of respondents were 'fully vaccinated' (had received COVID-19 bivalent vaccine), 54% [42%-67%] were partially vaccinated, and 13% [7%-19%] were unvaccinated. Fully vaccinated adults were more likely to consider COVID-19 bivalent vaccine 'very effective' (64%, [43%-86%]) at preventing hospitalization due to COVID-19 than partially (31%, [12%-50%]) or unvaccinated (2%, [0%-6%]) adults. Fully vaccinated adults were more likely to report COVID-19 bivalent vaccine was 'very safe' (83%, [69%-98%]) than partially (43%, [23%-63%]) or unvaccinated adults (2%, 0%-6%). Non-Hispanic White adults were more likely to report COVID-19 bivalent vaccine was 'very safe' (71%, [54%-87%]) than Non-Hispanic Black (36%, [21%-50%]) and Hispanic (26%, [7%-45%]) adults. A dose-response effect between vaccination status and perceptions of COVID-19 bivalent vaccine safety and effectiveness was observed, with fully vaccinated respondents having the most favorable attitudes. Racial and ethnic differences in perceived vaccine safety were also found. Improved communication about vaccine effectiveness and safety is key to improving low vaccination rates.
尽管接种疫苗是预防新冠病毒严重疾病最有效的手段，但新冠疫苗接种率仍在下降。2022年10月1日至2023年2月1日，我们在疫苗安全数据链中对成年人开展了一项横断面研究，了解他们对二价新冠病毒奥密克戎变异株加强疫苗（以下简称新冠二价疫苗）的态度和信念，并按接种状况、种族和族裔进行分层。分析对回答和选择偏倚进行了加权。回复率为27%（385/1430）；33%[95%置信区间：21%-44%]的受访者“完全接种”（已接种新冠二价疫苗），54%[42%-67%]部分接种，13%[7%-19%]未接种。完全接种的成年人比部分接种（31%，[12%-50%]）或未接种（2%，[0%-6%]）的成年人更有可能认为新冠二价疫苗在预防因新冠病毒导致的住院方面“非常有效”（64%，[43%-86%]）。完全接种的成年人比部分接种（43%，[23%-63%]）或未接种的成年人（2%，0%-6%）更有可能报告新冠二价疫苗“非常安全”（83%，[69%-98%]）。非西班牙裔白人成年人比非西班牙裔黑人（36%，[21%-50%]）和西班牙裔（26%，[7%-45%]）成年人更有可能报告新冠二价疫苗“非常安全”（71%，[54%-87%]）。在接种状况与对新冠二价疫苗安全性和有效性的认知之间观察到剂量反应效应，完全接种的受访者态度最为积极。在感知到的疫苗安全性方面也发现了种族和族裔差异。改善关于疫苗有效性和安全性的沟通是提高低接种率的关键。
