Scotto di Tella A M, Pauli A M, Dumoulin B, Benzina Z, Portugal H, Pastor J
Encephale. 1985 Mar-Apr;11(2):53-6.
A single administration (IP) of lithium chloride in the rat induces a decrease in erythrocyte calcium, proportional to the lithium level (p less than 0.01) and a diminution in cerebral calcium (p less than 0.001) which is accompanied by decrease in cerebral sodium and potassium levels (p less than 0.001). Repeated administration (IP + VO) has the same cerebral effects. The authors report that the reversible decrease in calcium, sodium and potassium, resulting from an increase in cerebral lithium levels, can be demonstrated on sampling at 1.30 and 3 hours (IP), or at 12 hours (VO). These results are relevant to the treatment of manic illnesses using calcium antagonists.
对大鼠腹腔注射一次氯化锂会导致红细胞钙含量降低，降低程度与锂水平成正比（p<0.01），同时脑钙含量减少（p<0.001），并伴有脑钠和钾水平降低（p<0.001）。重复给药（腹腔注射+灌胃）会产生相同的脑效应。作者报告称，脑锂水平升高导致的钙、钠和钾可逆性降低，在腹腔注射后1.5小时和3小时或灌胃后12小时取样时可以得到证实。这些结果与使用钙拮抗剂治疗躁狂症有关。
