Minot R, Crocq M A, Roussel B, Marie-Cardine M
Encephale. 1985 Mar-Apr;11(2):65-70.
This study reports the action of clovoxamine, a non-tricyclic non IMAO antidepressant, on the sleep parameters of five patients suffering from primary depressive illness. Before treatment all subjects presented an EEG syndrome of primary depressive sleep disorder (decreased paradoxical sleep latency). Sleep recordings were made after 1 month and 3 months of monotherapy with clovoxamine. PS latency increased to normal values, sleep efficiency improved and wake time decreased, and, more remarkably, paradoxical sleep was not suppressed by clovoxamine.
本研究报告了一种非三环类、非单胺氧化酶抑制剂（IMAO）的抗抑郁药氯伏沙明对五名原发性抑郁症患者睡眠参数的作用。治疗前，所有受试者均表现出原发性抑郁性睡眠障碍的脑电图综合征（快速眼动睡眠潜伏期缩短）。在使用氯伏沙明进行1个月和3个月的单一疗法后进行了睡眠记录。快速眼动睡眠潜伏期增加到正常值，睡眠效率提高，清醒时间减少，更值得注意的是，氯伏沙明并未抑制快速眼动睡眠。
