Al Jabri Amna, Cooke Jennie, Cournane Seán, Healy Marie-Louise
Sultan Qaboos University, Muscat, Oman.
Trinity College Dublin, Dublin, Ireland.
J Radiol Prot. 2025 Apr 22;45(2). doi: 10.1088/1361-6498/adc8b3.
The blood sampling required for the verification of dose delivered during radioactive iodine (I) therapy is a source of radiation exposure for healthcare staff. This study aims to estimate staff exposures, using Monte Carlo modelling, as well as experimental measurements. The study further aimed to validate the models with staff exposure measurements and examine the impact of protective measures on the procedure. The clinical set-up of blood sampling postI patient administration, within a dedicatedI ablation therapy suite, was modelled using EGSnrc Monte Carlo simulations (MCSs). The dose scoring regions representing deep dose (Hp(10)) and skin dose (Hp(0.07)) were estimated and validated with an experimental approach and clinical monitoring of staff members using electronic personal dosimeters. MCSs and experimental values did not show significant differences between the two approaches (> 0.05), with simulated values having lower uncertainties. It is demonstrated that the model is capable of being tailored to clinical scenarios at any centre. The simulations were corroborated with dosimetry data of blood sampling from 14 patients post administering 3.7 GBqI, amounting to a total of 54 measurements from 14 staff members. With the employed protective shielding, none of the staff were exposed to a dose rate approaching the annual dose constraint of 0.3 mSv.yr. The experimental and MCS data show good agreement with the clinical data, demonstrating the advantages of MCS approaches for providing useful information for planning and carrying out risk assessments before implementing a new dosimetry practice.
放射性碘（I）治疗期间用于验证给药剂量所需的血液采样是医护人员辐射暴露的一个来源。本研究旨在使用蒙特卡罗建模以及实验测量来估计工作人员的暴露情况。该研究还旨在通过工作人员暴露测量来验证模型，并检查防护措施对该操作的影响。在专门的I消融治疗套房内，对I给药后患者血液采样的临床设置进行了EGSnrc蒙特卡罗模拟（MCS）建模。使用电子个人剂量计对工作人员进行实验方法和临床监测，估计并验证了代表深部剂量（Hp(10)）和皮肤剂量（Hp(0.07)）的剂量评分区域。MCS和实验值在两种方法之间没有显示出显著差异（>0.05），模拟值的不确定性较低。结果表明，该模型能够针对任何中心的临床场景进行定制。模拟结果与14例患者在给予3.7GBqI后进行血液采样的剂量测定数据得到了证实，共计来自14名工作人员的54次测量。采用所使用的防护屏蔽后，没有一名工作人员暴露于接近0.3mSv.yr年度剂量约束的剂量率下。实验和MCS数据与临床数据显示出良好的一致性，证明了MCS方法在实施新的剂量测定实践之前为规划和进行风险评估提供有用信息方面的优势。
