Kanzaki Hanako, Suzuki Shiho, Tabata Tomotaka, Suzuki Taiki, Seto Yoshiya, Kaneko Kentaro
Department of Agricultural Chemistry, School of Agriculture, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki-shi, Kanagawa, 214-8571, Japan.
Sci Rep. 2025 Apr 3;15(1):11424. doi: 10.1038/s41598-025-95689-1.
Anxiety disorders are a leading cause of disability worldwide and major contributors to the global disease burden. In this study, we investigated the anxiolytic-like effects of plant-derived molecules in mice. Jasmonic acid (JA), a major plant hormone, has been identified as an injury response-related hormone in higher plants. We found that the oral, intraperitoneal, and intraventricular administration of JA in mice demonstrated anxiolytic-like effects in an elevated plus maze test. Additionally, JA exhibited anxiolytic-like effects in mice undergoing open field and novel environment feeding suppression tests. In addition, we found that the anxiolytic-like effects of JA were mediated by serotonin 5-HT1A receptors and central dopamine D1 receptor systems. Our findings reveal a novel role of JA in exerting anxiolytic-like effects in animals and suggest that plant hormones, such as JA, could serve as potential compounds for treating anxiety disorders.
焦虑症是全球致残的主要原因，也是全球疾病负担的主要促成因素。在本研究中，我们调查了植物源分子对小鼠的抗焦虑样作用。茉莉酸（JA）是一种主要的植物激素，已被确定为高等植物中与损伤反应相关的激素。我们发现，对小鼠口服、腹腔注射和脑室内注射JA在高架十字迷宫试验中表现出抗焦虑样作用。此外，JA在进行旷场试验和新环境摄食抑制试验的小鼠中也表现出抗焦虑样作用。此外，我们发现JA的抗焦虑样作用是由血清素5-HT1A受体和中枢多巴胺D1受体系统介导的。我们的研究结果揭示了JA在动物中发挥抗焦虑样作用的新作用，并表明植物激素，如JA，可作为治疗焦虑症的潜在化合物。
