Courriere P, Tremoulet M, Eche N, Armand J P
Eur J Cancer Clin Oncol. 1985 Jun;21(6):711-4. doi: 10.1016/0277-5379(85)90268-8.
Determination of cytosolic estradiol and progesterone receptors was carried out in 30 intracranial tumors: 12 meningiomas, 13 metastases, two angioreticulomas, two gliomas and one sarcoma. The hormonal fraction found with the receptor and the dissociation constant (Kd) were determined by the Scatchard method. Values higher than 10 fmol/mg of protein were considered as positive. Ten of the 12 meningiomas (83%) showed progesterone receptors (RP), while estrogen receptors (RE) were not found in any of the cases; six of the 13 metastases showed the two types of receptors; the other tumors did not present detectable receptor levels. There was no correlation between the receptor level and patient age, sex or hormonal status. Thee results suggest the possible use of endocrine therapy for example in cases of high-risk patients or incomplete surgical resection.
对30例颅内肿瘤进行了胞质雌二醇和孕酮受体的测定，其中包括12例脑膜瘤、13例转移瘤、2例血管母细胞瘤、2例胶质瘤和1例肉瘤。通过Scatchard法测定与受体结合的激素分数和解离常数（Kd）。蛋白质含量高于10 fmol/mg的值被视为阳性。12例脑膜瘤中有10例（83%）显示有孕酮受体（RP），而所有病例均未发现雌激素受体（RE）；13例转移瘤中有6例显示有两种类型的受体；其他肿瘤未检测到可检测的受体水平。受体水平与患者年龄、性别或激素状态之间无相关性。这些结果表明，内分泌治疗可能适用于例如高危患者或手术切除不完全的病例。
