Xu Feng, Zhang Juanjuan, Wu Iingzhi, Xu Youfu, Yu Taochun, Kang Jiliang, Wu Feiyan
Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, China.
Gannan Medical University, Ganzhou, Jiangxi, China.
BMC Oral Health. 2025 Apr 3;25(1):475. doi: 10.1186/s12903-025-05826-5.
The aim of this study is to conduct a systematic review to evaluate whether intra-articular injection of platelet-rich plasma (PRP) after joint puncture can aid in the recovery of patients with temporomandibular joint osteoarthritis (TMJOA).
We searched PubMed, Cochrane Library, Embase and Web of Science as of March 3, 2024. Retrieved a total of 392 articles. We included all published randomized controlled trials (RCTs). All RCTs, including studies on PRP injection after joint puncture in patients with TMJOA. The primary outcome was pain reduction, and the secondary outcome was the improvement of maximal mouth opening (MMO) and joint sounds. All outcome measures were analyzed by calculating the standardized mean differences (SMDs) and 95% confidence intervals (CIs).
A total of 392 articles were retrieved, and ultimately, 6 articles met the inclusion criteria. The study involved 199 TMJOA patients. The results indicated that compared to the control group, PRP injection after joint puncture showed significant improvements in alleviating pain (SMD =-0.99; 95% CI =-1.35 ~-0.63; P <0.00001, I = 59%) and MMO (SMD = 0.63; 95% CI = 0.30 ~ 0.95; P <0.0002, I = 54%) among TMJOA patients. However, there was no significant improvement observed in terms of joint sounds (SMD =-0.34; 95% CI = -0.71 ~ 0.02; P = 0.06, I = 0%) with the PRP.
Compared to joint puncture alone, the intra-articular injection of PRP after joint puncture was more effective in relieving pain. At 1-month and 6-month follow-ups, patients in the PRP group showed significant improvements in MMO compared to the control group. However, after 12 months of follow-up, limited evidence indicated significant improvements in MMO and joint sounds.
本研究旨在进行一项系统评价，以评估关节穿刺后关节腔内注射富血小板血浆（PRP）是否有助于颞下颌关节骨关节炎（TMJOA）患者的恢复。
截至2024年3月3日，我们检索了PubMed、Cochrane图书馆、Embase和科学网。共检索到392篇文章。我们纳入了所有已发表的随机对照试验（RCT）。所有RCT，包括关于TMJOA患者关节穿刺后PRP注射的研究。主要结局是疼痛减轻，次要结局是最大开口度（MMO）和关节弹响的改善。所有结局指标通过计算标准化均数差（SMD）和95%置信区间（CI）进行分析。
共检索到392篇文章，最终6篇文章符合纳入标准。该研究涉及199例TMJOA患者。结果表明，与对照组相比，关节穿刺后注射PRP在缓解TMJOA患者疼痛（SMD = -0.99；95%CI = -1.35 ~ -0.63；P <0.00001，I = 59%）和MMO（SMD = 0.63；95%CI = 0.30 ~ 0.95；P <0.0002，I = 54%）方面有显著改善。然而，PRP在关节弹响方面未观察到显著改善（SMD = -0.34；95%CI = -0.71 ~ 0.02；P = 0.06，I = 0%）。
与单纯关节穿刺相比，关节穿刺后关节腔内注射PRP在缓解疼痛方面更有效。在1个月和6个月的随访中，PRP组患者的MMO与对照组相比有显著改善。然而，在12个月的随访后，有限的证据表明MMO和关节弹响有显著改善。
