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某些神经肌肉阻断药物对耳螺中枢神经元乙酰胆碱兴奋性和抑制性反应的拮抗作用。

The antagonism of acetylcholine excitatory and inhibitory responses of Helix central neurones, by some neuromuscular blocking drugs.

作者信息

Bokisch A J, Hussain J, Palmer R A, Walker R J

出版信息

Eur J Pharmacol. 1985 Jun 19;112(3):405-9. doi: 10.1016/0014-2999(85)90788-5.

DOI:10.1016/0014-2999(85)90788-5
PMID:4018142
Abstract

Intracellular recordings were made from identified central neurones of the snail Helix aspersa. The antagonism of acetylcholine excitatory and inhibitory responses by d-tubocurarine, HS818 and HS626 was investigated. d-Tubocurarine was equipotent against both the inhibitory and excitatory responses, while HS626 and HS818 were of similar potency to d-tubocurarine in antagonising acetylcholine excitation but were approximately one order of magnitude less potent in antagonising the inhibitory response.

摘要

从鉴定出的蜗牛（即盖罩大蜗牛）中枢神经元进行细胞内记录。研究了d -筒箭毒碱、HS818和HS626对乙酰胆碱兴奋和抑制反应的拮抗作用。d -筒箭毒碱对抑制和兴奋反应的效力相同，而HS626和HS818在拮抗乙酰胆碱兴奋方面与d -筒箭毒碱效力相似，但在拮抗抑制反应方面效力约低一个数量级。

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