Duncan P G, Douglas J S
Eur J Pharmacol. 1985 Jun 19;112(3):423-7. doi: 10.1016/0014-2999(85)90792-7.
LTD4 was more potent in airway tissues from immature male and female guinea-pigs than in those from mature animals. The intrinsic activity of LTD4 relative to carbachol was greatest in tracheal tissues from immature animals. Indomethacin treatment reduced the potency of LTD4 and increased maximal contractile responses in most tissues. The reduced potency of LTD4 as a consequence of maturation may be significant for the decrease in airway reactivity seen in children at adolescence.
白三烯D4（LTD4）对未成熟豚鼠雌雄两性气道组织的作用比成熟动物气道组织更强。相对于卡巴胆碱，LTD4在未成熟动物气管组织中的内在活性最高。吲哚美辛处理降低了LTD4的效力，并增加了大多数组织中的最大收缩反应。LTD4因成熟导致的效力降低，可能对青春期儿童气道反应性降低具有重要意义。
