Komatsu M
Jikken Dobutsu. 1985 Apr;34(2):173-82. doi: 10.1538/expanim1978.34.2_173.
A two-way selective experiment for total hemolytic complement activity (CH50) was carried out in a colony of New Zealand White rabbits for the purpose of developing hereditary deficiency of complement component and estimating the realized heritability (h2) of CH50. The results obtained were as follows. 1) The mean value of CH50 with a standard error (SE) in 203 adults rabbits was 9.0 +/- 0.2 U/ml, and the range of CH50 was 2 to 18 U/ml. 2) Individual differences of CH50 in rabbits were comparatively stable regardless of time and season. 3) The realized heritability (h2) of CH50 was estimated to approximately 0.3. 4) Two rabbits with a hereditary C8 alpha-gamma deficiency were obtained from a cross between low CH50 individuals (male: 5.9 U/ml X female: 5.6 U/ml). From other crosses (male: 3.2 U/ml X female: 5.6, 5.7 U/ml), five rabbits with a hereditary C6 deficiency were obtained. 5) The frequencies of C8 alpha-gamma and C6 deficient genes in the colony were estimated to at least 0.005, 0.003, respectively. 6) It was suggested that a downward selection for CH50 was a useful method for developing hereditary deficiency of complement component in the rabbit.
为了培育补体成分遗传性缺陷并估计总溶血补体活性（CH50）的实现遗传力（h2），在一群新西兰白兔中进行了CH50的双向选择实验。获得的结果如下。1）203只成年兔的CH50平均值及标准误（SE）为9.0±0.2 U/ml，CH50范围为2至18 U/ml。2）兔CH50的个体差异无论时间和季节都相对稳定。3）CH50的实现遗传力（h2）估计约为0.3。4）从低CH50个体（雄性：5.9 U/ml×雌性：5.6 U/ml）的杂交中获得了两只遗传性C8α-γ缺陷兔。从其他杂交（雄性：3.2 U/ml×雌性：5.6、5.7 U/ml）中获得了五只遗传性C6缺陷兔。5）群体中C8α-γ和C6缺陷基因的频率估计分别至少为0.005、0.003。6）表明对CH50进行向下选择是培育兔补体成分遗传性缺陷的一种有用方法。
