Zambrano Ivan, Alcalde Juan, Iñarrairaegui Mercedes, Rotellar Fernando, Herrero J Ignacio
Department of Internal Medicine, School of Medicine, Universidad de Navarra, Pamplona, Spain.
Othorhinolaringology Department, Clínica Universidad de Navarra, Pamplona, Spain.
Front Oncol. 2025 Mar 13;15:1465123. doi: 10.3389/fonc.2025.1465123. eCollection 2025.
head and neck cancer is a common and severe complication than can occur after liver transplantation. However, it is unclear whether surveillance can help detect and prevent this type of cancer in liver transplant recipients.
We retrospectively examined 119 transplanted patients who had a smoking history above 20 pack-years. These patients underwent yearly evaluations by an ear-nose-throat specialist.
Twelve of them (10.1%) were diagnosed with head and neck cancer. The most significant risk factor for developing head and neck cancer was having been transplanted for alcoholic liver disease. Of the 12 diagnosed cases, six cases were diagnosed at an early-intermediate stage (stages 0-II), five were at an advanced stage (including one patient who was diagnosed at his first surveillance visit and two who did not attend the surveillance visits), and tumor stage was unknown in one case. Three patients had cancer recurrences, all of them had continued smoking after their initial diagnosis. The five-year actuarial survival rate after the diagnosis of head and neck cancer was 65.6%.
Annual surveillance for head and neck cancer may allow for early diagnosis and better survival rates after cancer diagnosis.
头颈癌是肝移植后可能出现的一种常见且严重的并发症。然而，目前尚不清楚监测是否有助于在肝移植受者中检测和预防这类癌症。
我们回顾性研究了119例有超过20包年吸烟史的移植患者。这些患者每年接受耳鼻喉科专家的评估。
其中12例（10.1%）被诊断为头颈癌。发生头颈癌最显著的危险因素是因酒精性肝病接受移植。在这12例确诊病例中，6例在早中期（0-II期）被诊断，5例处于晚期（包括1例在首次监测就诊时被诊断以及2例未参加监测就诊的患者），1例肿瘤分期未知。3例患者出现癌症复发，他们在初次诊断后均继续吸烟。头颈癌诊断后的五年精算生存率为65.6%。
对头颈癌进行年度监测可能有助于早期诊断并提高癌症诊断后的生存率。
