Burdette Rahim A, Whitt Caroline C, Behm Brian W, Warren Cirle A
School of Medicine, University of Virginia, Charlottesville, VA.
Department of Physical Medicine and Rehabilitation, University of Virginia, Charlottesville, VA.
ACG Case Rep J. 2025 Apr 3;12(4):e01660. doi: 10.14309/crj.0000000000001660. eCollection 2025 Apr.
Recurrent infection (rCDI) remains a major clinical challenge, often requiring fecal microbiota transplantation (FMT) after conventional treatment fails. An 86-year-old woman with rCDI underwent FMT after failing multiple antibiotic therapies. Shortly after FMT, she experienced diarrhea and abdominal pain, alongside positive stool tests. Antibiotics were withheld because of clinical improvement, and she achieved complete resolution of symptoms without further treatment. This case demonstrates the potential benefit of withholding antibiotics in rCDI patients soon after FMT to allow sufficient time for donor microbiota engraftment and underscores the need for further research to optimize post-FMT management.
复发性艰难梭菌感染（rCDI）仍然是一个重大的临床挑战，常规治疗失败后通常需要进行粪便微生物群移植（FMT）。一名86岁的rCDI女性在多种抗生素治疗失败后接受了FMT。FMT后不久，她出现腹泻和腹痛，同时粪便检测呈阳性。由于临床症状改善，停用了抗生素，她未经进一步治疗症状完全缓解。该病例表明，在FMT后不久对rCDI患者停用抗生素，以便为供体微生物群植入留出足够时间，可能具有益处，并强调需要进一步研究以优化FMT后的管理。
