硫利达嗪：体内过氧化物酶体β-氧化的选择性抑制剂。
Thioridazine: a selective inhibitor of peroxisomal beta-oxidation in vivo.
作者信息
Van den Branden C, Roels F
出版信息
FEBS Lett. 1985 Aug 5;187(2):331-3. doi: 10.1016/0014-5793(85)81270-9.
PMID:4018269
Abstract
In vivo administration of the phenothiazine drug, thioridazine, inhibits hepatic peroxisomal beta-oxidation in mice. In starving animals, 3-hydroxybutyrate concentration is not decreased by thioridazine treatment. These results provide the first demonstration of thioridazine as a selective inhibitor of peroxisomal beta-oxidation in intact animals. Thioridazine might supply a tool for simulation of pathological conditions in which peroxisomal beta-oxidation is impaired.
摘要
在小鼠体内施用吩噻嗪类药物硫利达嗪可抑制肝脏过氧化物酶体β-氧化。在饥饿的动物中，硫利达嗪处理不会降低3-羟基丁酸酯的浓度。这些结果首次证明硫利达嗪是完整动物体内过氧化物酶体β-氧化的选择性抑制剂。硫利达嗪可能为模拟过氧化物酶体β-氧化受损的病理状况提供一种工具。
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