Ibrahim Hani M G
Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Saudi J Ophthalmol. 2024 Mar 26;39(1):89-94. doi: 10.4103/sjopt.sjopt_164_23. eCollection 2025 Jan-Mar.
The purpose of this study was to study the role of the focal loss volume (FLV), global loss volume (GLV), and other spectral-domain optical coherence tomography (SD-OCT) parameters in early diagnosis of glaucomatous damage.
A retrospective study included records of 34 eyes with early glaucoma (Group A) and 17 eyes with suspicious optic discs (Group B). Retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and corneal thickness parameters were assessed by the SD OCT (RTVue SD-OCT). These included the FLV, GLV, in addition to RNFL thickness, cup/disc ratio, GCC thickness, and anterior segment OCT for assessment of central corneal thickness and central corneal epithelial thickness. Data from both groups were subjected to statistical analysis.
The FLV and GLV had the highest areas under the receiver operating characteristic curve in Group A eyes. FLV had higher (97.2%) specificity and was the earliest parameter to be affected by glaucomatous damage, followed by GLV. Moreover, Group A eyes had significant thinning of the RNFL (91.59 μm) compared to Group B (118.18 μm), and GCC thickness was also significantly thinner in Group A (92.07 μm) than in Group B (110.54 μm). Interestingly, Group A eyes had thinner corneal epithelium (nonsignificant) than Group B.
FLV and GLV were of the greatest value in the assessment of early glaucomatous GCC degeneration.
本研究旨在探讨局灶性丢失体积（FLV）、整体丢失体积（GLV）及其他光谱域光学相干断层扫描（SD - OCT）参数在青光眼性损害早期诊断中的作用。
一项回顾性研究纳入了34只早期青光眼患眼（A组）和17只视盘可疑患眼（B组）的记录。通过SD - OCT（RTVue SD - OCT）对视神经纤维层（RNFL）、神经节细胞复合体（GCC）和角膜厚度参数进行评估。这些参数包括FLV、GLV，以及RNFL厚度、杯盘比、GCC厚度，还有用于评估中央角膜厚度和中央角膜上皮厚度的眼前节OCT。对两组数据进行统计分析。
在A组患眼中，FLV和GLV在受试者操作特征曲线下面积最大。FLV具有较高的特异性（97.2%），是最早受青光眼性损害影响的参数，其次是GLV。此外，与B组（118.18μm）相比，A组患眼的RNFL显著变薄（91.59μm），且A组的GCC厚度（92.07μm）也明显薄于B组（110.54μm）。有趣的是，A组患眼角膜上皮比B组更薄（无统计学意义）。
FLV和GLV在评估早期青光眼性GCC退变方面价值最大。
