Ophthalmiatreio Eye Hospital of Athens, Athens, Greece.
J Glaucoma. 2021 Jan 1;30(1):44-49. doi: 10.1097/IJG.0000000000001677.
Patients with glaucoma have reduced and irregular corneal epithelial thickness (CET) even if they do not report symptoms of dry eyes. The reduction of corneal epithelium affects equally the superior and inferior areas of the cornea.
To evaluate CET parameters by means of anterior segment optical coherence tomography in glaucomatous patients undergoing medical treatment and compare them with CET parameters of controls.
This was a cross-sectional study of 62 patients with primary open-angle or pseudoexfoliative glaucoma (study group) and 62 age-matched controls. Fourier-domain optical coherence tomography (RTVue) with a corneal adaptor module was used in the present study. Τhe pachymetry scan pattern was used to map the cornea and the software generated corneal thickness parameters were recorded. Simple comparisons between groups were performed and the correlations of CET parameters with parameters associated with medication use (treatment duration, number of medications and number of instillations) were assessed.
Mean age of the patients was 68±11.9 years in the glaucoma group and 65.5±8.5, years in the control group (P=0.17). Median number of instillations of medication was 2 (range, 1 to 6) for the glaucoma group. Central corneal thickness was 537.6±33.3 in the glaucoma group and 550.8±33.7 in the control group, respectively (P=0.028). The central CET was 48.8.±3.7 μm in the glaucoma group and 53.5±3.7 μm in the control group (P<0.001). Similarly, the average superior (2 to 7 mm) CET and the average inferior (2 to 7 mm) CET were almost equally reduced in the glaucoma group (45±4 vs. 49.6±3.3 μm, P<0.001 and 49±3.9 vs 53.5±3.7, P<0.001, respectively). No CET parameter was correlated with any of the treatment parameters.
Patients treated for glaucoma have uniformly reduced corneal epithelial thickness.
即使青光眼患者没有报告干眼症症状，他们的角膜上皮厚度（CET）也会减少且不均匀。角膜上皮的减少会同样影响角膜的上、下区域。
通过眼前节光学相干断层扫描评估接受药物治疗的青光眼患者的 CET 参数，并将其与对照组的 CET 参数进行比较。
这是一项横断面研究，共纳入 62 例原发性开角型或假性剥脱性青光眼患者（研究组）和 62 名年龄匹配的对照者。本研究采用傅里叶域光学相干断层扫描仪（RTVue）和角膜适配模块。使用角膜厚度测绘图模式对角膜进行扫描，软件生成的角膜厚度参数被记录下来。对两组间的简单比较，并评估 CET 参数与药物使用相关参数（治疗持续时间、用药种类和用药次数）的相关性。
青光眼组患者的平均年龄为 68±11.9 岁，对照组为 65.5±8.5 岁（P=0.17）。青光眼组的平均用药次数为 2（范围，1 至 6）。青光眼组的中央角膜厚度为 537.6±33.3μm，对照组为 550.8±33.7μm（P=0.028）。青光眼组的中央 CET 为 48.8.±3.7μm，对照组为 53.5±3.7μm（P<0.001）。同样，青光眼组的平均上（2 至 7mm）和平均下（2 至 7mm）CET 几乎相等地减少（45±4μm 比 49.6±3.3μm，P<0.001 和 49±3.9μm 比 53.5±3.7μm，P<0.001）。没有 CET 参数与任何治疗参数相关。
接受青光眼治疗的患者的角膜上皮厚度普遍减少。
