Bresciani-Battilana Erica, Teixeira Ivan C, Barbosa Diego T Q, Caixeta-Umbelino Cristiano, Paolera Maurício D, Kasahara Niro
Department of Ophthalmology, Irmandade da Santa Casa de Misericordia de Sao Paulo, Santa Casa de Sao Paulo School of Medical Sciences, Rua Sao Mauro, 292, Sao Paulo, SP, 02526-050, Brazil.
Int Ophthalmol. 2015 Oct;35(5):645-50. doi: 10.1007/s10792-014-9988-7. Epub 2014 Sep 3.
To correlate the ganglion cell complex (GCC) parameters with structural measures of the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) as evaluated by Fourier-Domain optic coherence tomography (OCT). This retrospective study included patients with glaucoma, ocular hypertensive patients and glaucoma suspects who had previously undergone OCT examination with the RTVue-100. The parameters of GCC (average, superior, inferior, focal loss volume [FLV], global loss volume [GLV]) were correlated with the values of the ONH (cup volume, cup area, horizontal cup-to-disk ratio, vertical cup-to-disk ratio, and rim area) and RNFL (average, superior, and inferior) using Pearson's correlation coefficient. The sample included 74 eyes of 37 patients. All correlations between GCC parameters and RNFL were strong (r > 0.60). The correlation between GCC parameters and ONH were good for most parameters, except that for FLV and cup volume (r = 0.13), GLV and cup volume (r = 0.09), and GLV and cup area (r = 0.21). The GCC parameters can be used as structural measures of the glaucomatous optic neuropathy.
通过傅里叶域光学相干断层扫描（OCT）评估，将神经节细胞复合体（GCC）参数与视神经乳头（ONH）和视网膜神经纤维层（RNFL）的结构测量值进行关联。这项回顾性研究纳入了青光眼患者、高眼压症患者以及曾接受过RTVue - 100 OCT检查的青光眼疑似患者。使用Pearson相关系数将GCC的参数（平均值、上方、下方、局灶性丢失体积[FLV]、整体丢失体积[GLV]）与ONH的值（杯状体积、杯状面积、水平杯盘比、垂直杯盘比和边缘面积）以及RNFL的值（平均值、上方和下方）进行关联。样本包括37例患者的74只眼。GCC参数与RNFL之间的所有相关性都很强（r > 0.60）。GCC参数与ONH之间的相关性对于大多数参数来说较好，但FLV与杯状体积（r = 0.13）、GLV与杯状体积（r = 0.09）以及GLV与杯状面积（r = 0.21）除外。GCC参数可作为青光眼性视神经病变的结构测量指标。
