双相情感障碍中的认知能力与心理社会功能：BIPLONG研究的结果
Cognitive abilities and psychosocial functioning in bipolar disorder: findings from the BIPLONG study.
作者信息
Schönthaler Elena M D, Dalkner Nina, Stross Tatjana, Bengesser Susanne, Ilic Julia, Fellendorf Frederike, Finner Alexander, Fleischmann Eva, Häussl Alfred, Georgi Johanna, Maget Alexander, Lenger Melanie, Painold Annamaria, Platzer Martina, Queissner Robert, Schmiedhofer Franziska, Smolle Stefan, Tmava-Berisha Adelina, Reininghaus Eva Z
机构信息
Clinical Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
出版信息
Front Hum Neurosci. 2025 Mar 20;19:1479648. doi: 10.3389/fnhum.2025.1479648. eCollection 2025.
BACKGROUND
Bipolar disorder is associated with impairments in cognition and psychosocial functioning. Although these impairments occur frequently, often persist during euthymic times, and worsen quality of life, the impact of cognitive abilities on functioning has not yet been fully elucidated.
METHODS
The current study investigated the effects of cognitive domains (attention/psychomotor speed, verbal learning/memory, executive function) on psychosocial functioning cross-sectionally. Data from 210 euthymic individuals with bipolar disorder [101 female, 109 male; = 44.47; = 14.25] were included into the analysis. A neurocognitive test battery was administered and the Global Assessment of Functioning was used to depict psychosocial functioning. Correlation analyses were conducted to observe the associations between functioning and the cognitive domains. Moreover, three hierarchical regression analyses were applied to predict functioning by each of the cognitive domains, while considering age, sex, and education as control variables.
RESULTS
Correlation analyses revealed that functioning was positively associated with attention/psychomotor speed and verbal learning/memory. However, the consecutive hierarchical regression analyses found that none of the cognitive domains were able predict functioning beyond the control variables age, sex, and education.
CONCLUSION
Our findings indicate that greater abilities in the domains of attention/psychomotor speed and verbal learning/memory are associated with better functioning. However, this association can be explained by other relevant variables such as age or education, indicating that cognitive abilities are not the sole contributor of psychosocial functioning. Investigating other measurements of functioning or cognitive abilities could lead to different results. Nevertheless, promoting cognitive abilities and autonomy in daily life remains an important aspect of therapy in bipolar disorder.
背景
双相情感障碍与认知及心理社会功能受损有关。尽管这些损害频繁发生，常在心境正常期持续存在，并使生活质量恶化，但认知能力对功能的影响尚未完全阐明。
方法
本研究横断面调查了认知领域（注意力/精神运动速度、言语学习/记忆、执行功能）对心理社会功能的影响。分析纳入了210名双相情感障碍心境正常个体的数据[101名女性，109名男性；平均年龄 = 44.47岁；标准差 = 14.25岁]。实施了一套神经认知测试，并使用功能总体评定量表来描述心理社会功能。进行相关性分析以观察功能与认知领域之间的关联。此外，应用三个层次回归分析，在将年龄、性别和教育作为控制变量的情况下，通过每个认知领域预测功能。
结果
相关性分析显示，功能与注意力/精神运动速度和言语学习/记忆呈正相关。然而，连续的层次回归分析发现，没有一个认知领域能够在控制变量年龄、性别和教育之外预测功能。
结论
我们的研究结果表明，注意力/精神运动速度和言语学习/记忆领域能力越强，功能越好。然而，这种关联可以由年龄或教育等其他相关变量来解释，这表明认知能力并非心理社会功能的唯一影响因素。研究功能或认知能力的其他测量方法可能会得出不同结果。尽管如此，提高认知能力和日常生活中的自主性仍然是双相情感障碍治疗的一个重要方面。
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