Yang Jun-Jie, He Sha-Qi, Huang Bei, Wang Peng-Xin, Xu Feng, Lin Xiao, Liu Jun
Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Department of Radiology, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Front Pharmacol. 2025 Mar 13;16:1550208. doi: 10.3389/fphar.2025.1550208. eCollection 2025.
With the rapid development of extracellular vesicles (EVs) in regenerative medicine research, they have become a promising new direction in the mechanistic, diagnosis and treatment studies of degenerative musculoskeletal diseases (DMDs), and has attracted increasing attention. However, there is currently a lack of comprehensive and objective summary analysis to help researchers quickly and conveniently understand the development trajectory and future trends of this field.
This study collected articles and reviews published from 2006 to 2024 on EVs in DMDs from the Web of Science database. Bibliometric and visual analysis was conducted using several tools, including Microsoft Excel Office, VOSviewer, CiteSpace, Pajek, and R packages.
1,182 publications were included in the analysis from 2006 to 2024. Notably, there was a rapid increase in the number of publications starting in 2016, suggesting that this field remains in a developmental stage. Co-authorship analysis revealed that China ranked first in terms of publications, whereas the United States led in citations. The journal with the highest number of publications was International Journal of Molecular Sciences (INT J MOL SCI). The most prolific authors were Ragni, E with 23 publications, while the most cited author was Toh, WS. Additionally, nine of the top 10 institutions were from China, with Shanghai Jiao Tong University leading in the number of publications. The most cited article was "MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity", authored by Zhang, S, and published in BIOMATERIALS in 2018.
This study, through bibliometric and visual analysis, clearly illustrates the collaborative relationships among countries, authors, institutions, and journals, providing valuable insights for researchers seeking academic collaboration opportunities. Moreover, the analysis of keywords and citations allows researchers to better understand key research hotspots and frontiers in this field, and points toward promising directions for future research. The growing interest in EV research in DMDs over recent years indicates increasing attention and a dynamic progression in this field.
随着细胞外囊泡（EVs）在再生医学研究中的迅速发展，它们已成为退行性肌肉骨骼疾病（DMDs）机制、诊断和治疗研究中一个有前景的新方向，并日益受到关注。然而，目前缺乏全面客观的总结分析，以帮助研究人员快速便捷地了解该领域的发展轨迹和未来趋势。
本研究从科学网数据库收集了2006年至2024年发表的关于DMDs中EVs的文章和综述。使用了多种工具进行文献计量和可视化分析，包括Microsoft Excel Office、VOSviewer、CiteSpace、Pajek和R软件包。
2006年至2024年的分析共纳入1182篇出版物。值得注意的是，从2016年开始出版物数量迅速增加，表明该领域仍处于发展阶段。合作作者分析显示，中国在出版物数量方面排名第一，而美国在被引频次方面领先。发表文章数量最多的期刊是《国际分子科学杂志》（INT J MOL SCI）。发文量最多的作者是Ragni, E，有23篇出版物，而被引频次最高的作者是Toh, WS。此外，排名前十的机构中有九个来自中国，上海交通大学在出版物数量方面领先。被引频次最高的文章是Zhang, S等人于2018年发表在《生物材料》上的“间充质干细胞外泌体通过增强增殖、减轻凋亡和调节免疫反应介导软骨修复”。
本研究通过文献计量和可视化分析，清晰地展示了国家、作者、机构和期刊之间的合作关系，为寻求学术合作机会的研究人员提供了有价值的见解。此外，对关键词和被引频次的分析使研究人员能够更好地理解该领域的关键研究热点和前沿，并指出未来研究的有前景方向。近年来对DMDs中EV研究的兴趣日益浓厚，表明该领域受到越来越多的关注且发展动态良好。
