Luo Zhi Qiang, Zhou Biao, Xiong Hui
Department of Graduate School, Hunan University of Chinese Medicine, Changsha City, Hunan Province, People's Republic of China.
Department of Orthopedics, Xiangtan First People's Hospital, Xiangtan City, Hunan Province, People's Republic of China.
J Pain Res. 2023 Jun 26;16:2171-2188. doi: 10.2147/JPR.S407050. eCollection 2023.
Osteoarthritis (OA) is a common clinical disease characterized by the destruction of articular cartilage, subchondral ossification, cystic degeneration and osteophyte formation. Recently, more and more scholars draw attention to exosomes in the field of OA, and exciting breakthroughs have been achieved in recent years. However, bibliometric analysis of the literature in this research field is lacking. Considering its potential in treatment of OA, this article aimed to analyze the research status and identify future hotspots of exosomes in osteoarthritis in recent 10 years by bibliometrics tools.
Relevant publications in this field from 2012 to 2022 was retrieved from the Web of Science core collection database (WOSSCC). And we used Vosviewers, CiteSpace, an online analysis platform and the R package "Bibliometrix" for bibliometric analysis.
A total of 484 publications (including 319 articles and 165 reviews) from 51 countries, 720 institutions, were included in this study. IRCCS Ist Ortoped Galeazzi, Shanghai Jiao Tong University, and Sun Yat-sen University are the leading research institutions in this field. contributed the largest number of articles, and is the most co-cited journal. Of the 2664 scholars who participated in the study, Ragni E, De Girolamo L, Orfei CP, and Colombini A had the largest number of articles. Zhang, SP is the most co-cited author. "Mesenchymal stem cell", "biomaterials", "Inflammation" and "regenerative medicine" are the keywords in the research.
This is the first bibliometric analysis of exosomes in osteoarthritis. We explored current research status in recent years and identified frontiers and hot spots in this research field. We highlight the significant roles of mesenchymal stem cell-derived exosomes (MSC-Exos) in the treatment of osteoarthritis, and identified exosomal biomaterials as frontier in this research domain, which can provide reference for the researchers who focus on this research field.
骨关节炎（OA）是一种常见的临床疾病，其特征为关节软骨破坏、软骨下骨化、囊性退变和骨赘形成。近年来，越来越多的学者关注到OA领域中的外泌体，且近年来已取得了令人振奋的突破。然而，该研究领域的文献计量学分析尚属欠缺。鉴于其在OA治疗中的潜力，本文旨在通过文献计量学工具分析近10年骨关节炎中外泌体的研究现状并确定未来热点。
从Web of Science核心合集数据库（WOSSCC）中检索2012年至2022年该领域的相关出版物。我们使用Vosviewers、CiteSpace、一个在线分析平台以及R包“Bibliometrix”进行文献计量学分析。
本研究共纳入来自51个国家、720个机构的484篇出版物（包括319篇文章和165篇综述）。IRCCS Ist Ortoped Galeazzi、上海交通大学和中山大学是该领域的主要研究机构。发表文章数量最多， 是被引频次最高的期刊。在参与研究的2664位学者中，Ragni E、De Girolamo L、Orfei CP和Colombini A发表的文章数量最多。张SP是被引频次最高的作者。“间充质干细胞”“生物材料”“炎症”和“再生医学”是研究中的关键词。
这是首次对骨关节炎中外泌体进行的文献计量学分析。我们探究了近年来的研究现状，并确定了该研究领域的前沿和热点。我们强调了间充质干细胞衍生外泌体（MSC-Exos）在骨关节炎治疗中的重要作用，并将外泌体生物材料确定为该研究领域的前沿，可为专注于该研究领域的研究人员提供参考。
