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对化学成分、药理学、质量控制及临床应用的全面综述

: a comprehensive review of the chemical constituents, pharmacology, quality control and clinical applications.

作者信息

Jiao Xingmeng, Jin Qiong, Zhu Peifeng, Tan Zhuomin, Li Li, Liu Lu

机构信息

School of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, China.

College of Pharmacy, Kunming Medical University, Kunming, China.

出版信息

Front Pharmacol. 2025 Mar 13;16:1452797. doi: 10.3389/fphar.2025.1452797. eCollection 2025.

Abstract

(CS), is an herbaceous perennial belonging to the family Lamiaceae. The herb is extensively employed in traditional Chinese medicine for the mitigation of nephritis, cystitis, kidney stones, urological tract stones, gout, and other urinary conditions. Numerous research studies have been conducted in the past to explore the traditional medicinal value, phytochemical composition, pharmacological effects, and quality control measures associated with this plant. This has motivated us to systematically search various online databases such as Google Scholar, PubMed, Science Direct, Elsevier, CNKI, Scopus, Embase, and Web of Science using specific keywords to get the most recent research information findings related to this plant. Phytochemical investigations have identified that this plant predominantly contains flavonoids, terpenoids, phenylpropanoids, and volatile oil compounds. Certain constituents have been employed as markers in quality assessment research, and some were recognized as bioactive agents in the management of specific ailments. These components have demonstrated notable effectiveness in combating bacterial infections, reducing inflammation, providing antioxidant properties, managing hyperuricemia, and offering renal protection. Notably, clinical trials have confirmed its remarkable efficacy in treating urinary inflammation and stones. We acquired recent research findings concerning CS in the fields of phytochemistry, pharmacology, quality control, and clinical applications via online search. These findings have been summarized and analysed to offer a valuable reference for further comprehensive research, development, and utilization of CS.

摘要

(CS)是一种多年生草本植物,属于唇形科。这种草药在传统中医中被广泛用于缓解肾炎、膀胱炎、肾结石、泌尿道结石、痛风和其他泌尿系统疾病。过去已经进行了许多研究,以探索与这种植物相关的传统药用价值、植物化学成分、药理作用和质量控制措施。这促使我们使用特定关键词系统地搜索各种在线数据库,如谷歌学术、PubMed、科学Direct、爱思唯尔、中国知网、Scopus、Embase和科学网,以获取与这种植物相关的最新研究信息。植物化学研究已经确定,这种植物主要含有黄酮类化合物、萜类化合物、苯丙素类化合物和挥发油化合物。某些成分已被用作质量评估研究的标志物,一些被认为是治疗特定疾病的生物活性剂。这些成分在对抗细菌感染、减轻炎症、提供抗氧化特性、管理高尿酸血症和提供肾脏保护方面已显示出显著效果。值得注意的是,临床试验已经证实其在治疗泌尿系统炎症和结石方面具有显著疗效。我们通过在线搜索获得了关于CS在植物化学、药理学、质量控制和临床应用领域的最新研究结果。对这些结果进行了总结和分析,为CS的进一步全面研究、开发和利用提供有价值的参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca5/11966054/9c8e4901f1aa/fphar-16-1452797-g001.jpg

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