Parry M F, Neu H C
J Clin Microbiol. 1977 Jan;5(1):58-61. doi: 10.1128/jcm.5.1.58-61.1977.
The antibiotic bacerial inactivity of N-acetylcysteine (NAC) and its interaction with penicillin and aminocyclitol antibiotics was evaluated. NAC inhibited growth of both gram-negative and gram-positive bacteria. Strains of Pseudomonas aeruginosa were more susceptible than other microorgainsms tested. P. aeruginosa strains were inhibited synergistically by NAC and carbenicillin or ticarcillin. However, NAC antagonized the activity of gentamicin and tobramycin. These findings have implications for the combined clinical use of NAC and aerosolized antibiotics and are also important for the processing of sputum specimens in the microbiology laboratory.
评估了N-乙酰半胱氨酸（NAC）的抗生素细菌失活作用及其与青霉素和氨基环醇类抗生素的相互作用。NAC抑制革兰氏阴性菌和革兰氏阳性菌的生长。铜绿假单胞菌菌株比其他测试微生物更敏感。NAC与羧苄青霉素或替卡西林协同抑制铜绿假单胞菌菌株。然而，NAC拮抗庆大霉素和妥布霉素的活性。这些发现对NAC与雾化抗生素的联合临床应用具有启示意义，对微生物实验室痰标本的处理也很重要。
