关于抗生素在体外穿透黏液的一些观察
Some observations on the penetration of antibiotics through mucus in vitro.
作者信息
Saggers B A, Lawson D
出版信息
J Clin Pathol. 1966 Jul;19(4):313-7. doi: 10.1136/jcp.19.4.313.
Abstract
A study has been made on the penetration values in vitro of antibiotics through hog gastric mucin at pH 7.4. Determinations have also been done on the binding of antibiotics to mucus and human plasma. The mucolytic agent N-acetyl cysteine has been studied in regard to its effect on antibiotics penetrating mucus and for any possible inactivation of antibiotics.
摘要
已对多种抗生素在pH 7.4条件下透过猪胃粘蛋白的体外渗透值进行了研究。还测定了抗生素与粘液及人血浆的结合情况。对溶粘蛋白剂N - 乙酰半胱氨酸在其对抗生素穿透粘液的影响以及抗生素可能的失活方面进行了研究。
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