Stefan Krennmair, Michael Weinländer, Uwe-Yalcin Schwarze, Michael Malek, Thomas Forstner, Gerald Krennmair
Department of Oral and Maxillofacial Surgery, Keplerklinikum Linz, Johannes Kepler University (JKU) Linz, Linz, Austria.
Num-Biolab, Ludwig-Maximilian University (LMU), Munich, Germany.
Clin Implant Dent Relat Res. 2025 Apr;27(2):e70014. doi: 10.1111/cid.70014.
The present study aimed to evaluate and to compare the influence of anatomical variables such as sinus width (SW), inner maxillary sinus contour length (IMSCL), and residual ridge height (RRH) on new bone formation (%NBF) for deproteinized porcine (DPBM) and bovine bone mineral (DBBM) used for lateral window sinus augmentation (LWSA) grafting.
For LWSA groups grafted either with DPBM (n = 10) or DBBM (n = 13) a linear- as well as a multivariate-regression analysis was conducted between measured %NBF and radiographically retrospectively assessed anatomical variables (SW/IMSCL/RRH). Correlations as well as regression coefficients (R) were calculated, evaluating the influence of anatomical variables on %NBF with differentiation between both xenogenic graft materials used.
With no differences for patient-epidemiologic data, for anatomical variables as well as for surgical- and patient-related risk factors, comparison between the two LWSA groups was possible. The linear-regression analysis provided significant correlations between histomorphometrically evaluated %NBF and SW (DPBM: r = -0.660, p = 0.038; DBBM: r = -0.614, p = 0.026) as well as between %NBF and IMSCL (DPBM: r = -0.737; p = 0.015, DBBM: r = -0.573, p = 0.041), but not for RRH. Between SW/IMSCL/RRH and %NBF, regression-coefficients-(R) of 0.435/0.543/0.258 using DPBM and R of 0.377/0.328/0.053 using DBBM represented evidently higher influences of anatomical structures when porcine graft material was applied. The multivariate-regression analysis confirmed the different influence between various xenogenic graft materials on % NBF as well with a pronounced effect for porcine material (DPBM: R = 0.591 [59.1%] vs. DBBM: R = 0.314 [31.4%]).
In LWSA, anatomical structures such as SW and IMSCL significantly affect new bone formation, though with varying effects for different xenogenic (porcine vs. bovine) bone mineral graft materials used.
本研究旨在评估并比较诸如窦宽度（SW）、上颌窦内侧轮廓长度（IMSCL）和剩余牙槽嵴高度（RRH）等解剖学变量对用于外侧开窗上颌窦提升（LWSA）植骨的脱蛋白猪骨（DPBM）和牛骨矿物质（DBBM）新骨形成（%NBF）的影响。
对于分别用DPBM（n = 10）或DBBM（n = 13）进行LWSA植骨的组，在测量的%NBF与通过影像学回顾性评估的解剖学变量（SW/IMSCL/RRH）之间进行线性和多变量回归分析。计算相关性以及回归系数（R），评估解剖学变量对%NBF的影响，并区分所使用的两种异种移植材料。
在患者流行病学数据、解剖学变量以及手术和患者相关风险因素方面无差异，因此可以对两个LWSA组进行比较。线性回归分析显示，组织形态计量学评估的%NBF与SW之间存在显著相关性（DPBM：r = -0.660，p = 0.038；DBBM：r = -0.614，p = 0.026），%NBF与IMSCL之间也存在显著相关性（DPBM：r = -0.737；p = 0.015，DBBM：r = -0.573，p = 0.041），但与RRH无显著相关性。在SW/IMSCL/RRH与%NBF之间，使用DPBM时回归系数（R）分别为0.435/0.543/0.258，使用DBBM时R分别为0.377/0.328/0.053，这表明应用猪源移植材料时解剖结构的影响明显更大。多变量回归分析证实了不同异种移植材料对%NBF的不同影响，猪源材料的影响更为显著（DPBM：R = 0.591 [59.1%] 对 DBBM：R = 0.314 [31.4%]）。
在LWSA中，诸如SW和IMSCL等解剖结构显著影响新骨形成，尽管对所使用的不同异种（猪源与牛源）骨矿物质移植材料的影响有所不同。
