Liu Jian, He Miao, Song Ruoyu, Li Jie
Department of Orthopaedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), No. 1 Jiankang Road, Chongqing, 400010, China.
BMC Geriatr. 2025 Apr 5;25(1):222. doi: 10.1186/s12877-025-05875-z.
This study aims to explore the association between deep vein thrombosis (DVT) of the lower limbs at admission and the time from injury to admission (TFITA), providing clinical references for the prevention of DVT at admission.
Data was collected from patients who were admitted to our hospital for hip fractures between January 2017 and December 2023. Univariable and multivariable logistic regression analyses were conducted to examine the relationship between TFITA and DVT at admission, using both continuous and categorized variables based on thresholds for TFITA. Propensity score matching (PSM) and subanalyses stratified by TFITA and characteristics of DVT at admission were further employed to investigate the relationship. Additionally, restricted cubic splines (RCS) analysis was performed to determine whether a non-linear association exists between TFITA and DVT at admission.
A total of 1230 patients were included in the statistical analysis, comprising 116 patients with DVT at admission and 1114 without. Both Univariable and multivariable logistic regression analyses indicated a positive association between TFITA and DVT at admission before and after matching. Subanalyses revealed significant associations for older age, low-energy injuries, high D-dimer levels, and low platelet counts subgroup with TFITA and DVT at admission. RCS analysis indicated no non-linear relationship between TFITA and DVT at admission.
For patients with hip fractures, longer TFITA is positively correlated with the incidence of DVT at admission. These findings support the potential of TFITA as an intervention strategy for managing DVT at admission.
本研究旨在探讨入院时下肢深静脉血栓形成（DVT）与受伤至入院时间（TFITA）之间的关联，为入院时DVT的预防提供临床参考。
收集2017年1月至2023年12月期间因髋部骨折入住我院的患者的数据。进行单变量和多变量逻辑回归分析，以检验TFITA与入院时DVT之间的关系，使用基于TFITA阈值的连续变量和分类变量。进一步采用倾向得分匹配（PSM）以及按TFITA和入院时DVT特征分层的亚分析来研究这种关系。此外，进行受限立方样条（RCS）分析以确定TFITA与入院时DVT之间是否存在非线性关联。
共有1230例患者纳入统计分析，其中入院时发生DVT的患者116例，未发生DVT的患者1114例。单变量和多变量逻辑回归分析均表明，匹配前后TFITA与入院时DVT之间存在正相关。亚分析显示，年龄较大、低能量损伤、D-二聚体水平高以及血小板计数低亚组与TFITA和入院时DVT之间存在显著关联。RCS分析表明，TFITA与入院时DVT之间不存在非线性关系。
对于髋部骨折患者，较长的TFITA与入院时DVT的发生率呈正相关。这些发现支持TFITA作为入院时管理DVT的一种干预策略的潜力。
