Epigenetic insights of olanzapine-induced insulin resistance.
作者信息
Frond David, Rettig Adam, Burghardt Kyle
机构信息
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
出版信息
Epigenomics. 2025 Jun;17(8):507-509. doi: 10.1080/17501911.2025.2489341. Epub 2025 Apr 4.
Abstract
摘要
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本文引用的文献
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DNA methylation and histone modifications associated with antipsychotic treatment: a systematic review.与抗精神病药物治疗相关的DNA甲基化和组蛋白修饰：一项系统综述。
Mol Psychiatry. 2025 Jan;30(1):296-309. doi: 10.1038/s41380-024-02735-x. Epub 2024 Sep 3.
2
Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers.骨骼肌胰岛素信号DNA甲基化的改变：奥氮平在健康志愿者中的一项随机对照试验。
Biomedicines. 2024 May 10;12(5):1057. doi: 10.3390/biomedicines12051057.
3
DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study.DNA 甲基化可能部分解释精神药物引起的代谢副作用：来自前瞻性 1 个月观察研究的结果。
Clin Epigenetics. 2024 Feb 28;16(1):36. doi: 10.1186/s13148-024-01648-4.
4
Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia.表观遗传组蛋白甲基化的 PPARγ 和 CPT1A 信号转导有助于倍他司汀预防奥氮平引起的血脂异常。
Int J Mol Sci. 2023 May 23;24(11):9143. doi: 10.3390/ijms24119143.
5
Olanzapine-induced decreases of FGF21 in brown adipose tissue via histone modulations drive UCP1-dependent thermogenetic impairment.奥氮平通过组蛋白修饰导致棕色脂肪组织中 FGF21 的减少，从而导致 UCP1 依赖性生热损伤。
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Mar 2;122:110692. doi: 10.1016/j.pnpbp.2022.110692. Epub 2022 Dec 9.
6
Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes.多组学分析鉴定出瘦素/PPAR 基因簇中的罕见变异，以及 ABCG1 的高甲基化导致抗精神病药物引起的代谢综合征。
Mol Psychiatry. 2022 Dec;27(12):5195-5205. doi: 10.1038/s41380-022-01759-5. Epub 2022 Sep 5.
7
Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders.组蛋白的表观遗传修饰作用于过氧化物酶体增殖物激活受体 γ 及其相关通路，从而导致奥氮平引起的代谢紊乱。
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