维生素D受体：散发性甲状旁腺腺瘤的一种可能生物标志物？

Vitamin D receptor: a possible biomarker for sporadic parathyroid adenoma?

作者信息

Chorti Angeliki, Cheva Angeliki, Boulogeorgou Kassiani, Chatzikyriakidou Anthoula, Achilla Charoula, Tsalkatidou Despoina, Krokou Despoina, Bakkar Sohail, Theodossis Papavramidis

机构信息

1st Propaedeutic Department of Surgery, Faculty of Health Science, Medical School, AHEPA University Hospital, Aristotle University, St.Kiriakidi 1, 54636, Thessaloniki, Greece.

Laboratory of Pathology, Faculty of Health Science, Medical School, Aristotle University, Thessaloniki, Greece.

出版信息

Updates Surg. 2025 Apr 5. doi: 10.1007/s13304-025-02182-5.

DOI:10.1007/s13304-025-02182-5

PMID:40186735

Abstract

Parathyroid adenoma is the main cause of primary hyperparathyroidism. The genetic basis of the disease is still unclear. Vitamin D receptor (VDR) is involved in parathormone regulation. The aim of this study is to evaluate Vitamin D receptor expression in sporadic parathyroid adenoma. Fifty-one patients with parathyroid adenoma and 51 healthy volunteers were enrolled in the study and genetic and immunohistochemical studies were conducted. VDR polymorphism TaqI was correlated with parathyroid adenoma development, while VDR stained positive in immunohistochemical study. Our study suggests VDR as a major contributor to sporadic parathyroid adenoma formation in Greek population.

摘要

甲状旁腺腺瘤是原发性甲状旁腺功能亢进的主要病因。该疾病的遗传基础仍不清楚。维生素D受体（VDR）参与甲状旁腺激素的调节。本研究的目的是评估散发性甲状旁腺腺瘤中维生素D受体的表达情况。51例甲状旁腺腺瘤患者和51名健康志愿者参与了本研究，并进行了基因和免疫组织化学研究。VDR多态性TaqI与甲状旁腺腺瘤的发生相关，而在免疫组织化学研究中VDR呈阳性染色。我们的研究表明，在希腊人群中VDR是散发性甲状旁腺腺瘤形成的主要促成因素。