Ortega L, Landa Garcia J I, Torres Garcia A, Silecchia G, Arenas J, Suarez A, Moreno Azcoitia M, Sanz Esponera J, Moreno Gonzalez E, Balibrea Cantero J L
Hepatology. 1985 Jul-Aug;5(4):673-6. doi: 10.1002/hep.1840050425.
Results concerning morphological and biochemical changes following intravenous administration of different doses of acetaminophen in dogs are reported. Acetaminophen infusion, as a parenteral solution (500 mg per kg per 90 min), produced fulminant hepatitis characterized by a good correlation between Portmann's grade of lesion and percentage of necrosis. All animals died within 76 hr after intoxication. Analysis of biochemical parameters revealed positive correlation between serum bilirubin levels and severity of the hepatic lesion. The experimental model of acetaminophen-induced hepatotoxicity is proposed as a model for evaluation of the therapeutic efficacy of new medical and surgical procedures.
报告了犬静脉注射不同剂量对乙酰氨基酚后形态学和生化变化的结果。以肠胃外溶液形式输注对乙酰氨基酚（每千克每90分钟500毫克）会引发暴发性肝炎，其特征为波特曼损伤分级与坏死百分比之间具有良好的相关性。所有动物在中毒后76小时内死亡。生化参数分析显示血清胆红素水平与肝脏损伤严重程度之间呈正相关。对乙酰氨基酚诱导的肝毒性实验模型被提议作为评估新的医学和外科手术治疗效果的模型。
