Gazzard B G, Hughes R D, Mellon P J, Portmann B, Williams R
Br J Exp Pathol. 1975 Oct;56(5):408-11.
Oral administration of graded doses of paracetamol to dogs produced hepatic necrosis with some similarities to the clinical syndrome seen in man following a paracetamol overdose. Coma, with raised levels of arterial ammonia, was produced and the aspartate aminotransferase levels became markedly elevated in 2 animals who survived more than 24 h. However, the extent of the hepatic necrosis and the time of survival following paracetamol administration were too variable for this model to be of value for the testing of new methods of temporary liver support. When paracetamol was given by intraperitoneal injection many of the animals died of respiratory distress. Significant methaemoglobinaemia was detected, which was associated with a reduction in the arterial partial pressure of oxygen and was partly reversed by the administration of methylene blue.
给狗口服不同剂量的对乙酰氨基酚会导致肝坏死，这与人类过量服用对乙酰氨基酚后出现的临床综合征有一些相似之处。会出现昏迷，动脉血氨水平升高，在存活超过24小时的2只动物中，天冬氨酸转氨酶水平显著升高。然而，对乙酰氨基酚给药后肝坏死的程度和存活时间变化太大，以至于该模型对于测试新的临时肝脏支持方法没有价值。当通过腹腔注射给予对乙酰氨基酚时，许多动物死于呼吸窘迫。检测到显著的高铁血红蛋白血症，这与动脉血氧分压降低有关，并且通过给予亚甲蓝部分得到逆转。
