Sahoo Ipshita, Rajaram Shalini, Tiwari Parmita, Durgapal Prashant
Department of Obstetrics and Gynecology (Gynecologic Oncology), AIIMS Rishikesh, Rishikesh, Uttarakhand, India.
Department of Obstetrics and Gynecology (Gynecologic Oncology), AIIMS Rishikesh, Rishikesh, Uttarakhand, India
BMJ Case Rep. 2025 Apr 5;18(4):e262353. doi: 10.1136/bcr-2024-262353.
Ovarian Sertoli Leydig cell tumours (SLCTs) are rare and occur predominantly in young females. Categorised as less common ovarian cancers, they have a favourable prognosis, and fertility preservation is an option in early-stage disease, where fertility is desired. Here, we describe a case of a late adolescent girl, who presented after tumour excision of left ovarian mass. Her initial histopathology report showed mucinous adenocarcinoma of left ovary. Slide review and immunohistochemistry suggested stage IC, intermediate grade Sertoli Leydig cell tumour and the patient was kept on observation. Six months later, she underwent re-surgery with fertility preservation for suspected recurrence. Final histopathology showed no residual tumour. The girl has been disease-free for 4 years. This case highlights the importance of immunohistochemistry and extensive pathology review for diagnosis of this rare tumour. It emphasises that SLCT can masquerade as other poor-grade malignancies owing to histopathological overlap.
卵巢支持-间质细胞瘤（SLCT）较为罕见，主要发生于年轻女性。作为较罕见的卵巢癌，其预后良好，对于有生育需求的早期疾病患者，保留生育功能是一种选择。在此，我们描述一例青春期晚期女孩的病例，她在左侧卵巢肿物切除术后前来就诊。其最初的组织病理学报告显示左侧卵巢黏液腺癌。玻片复查及免疫组化提示为IC期、中级别的支持-间质细胞瘤，该患者接受观察。六个月后，因怀疑复发，她接受了保留生育功能的再次手术。最终组织病理学检查显示无残留肿瘤。该女孩已无病生存4年。此病例凸显了免疫组化及全面病理检查对于诊断这种罕见肿瘤的重要性。它强调由于组织病理学上的重叠，支持-间质细胞瘤可能会伪装成其他低级别恶性肿瘤。
