Department of Gynecology and Obstetrics, The Affiliated Hospital of Qingdao University, NO.16 Jiangsu Road, Qingdao, 266000, Shandong, China.
Qingdao University, Qingdao, China.
J Ovarian Res. 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7.
Because of limited information of Sertoli-Leydig cell tumors (SLCTs), the objective aimed to describe clinical parameters, management and treatment results of SLCTs.
We retrospectively reviewed 15 cases with SLCTs, who were treated in the Affiliated Hospital of Qingdao University between 2009 and 2020. Data of clinical parameters and treatment was studied.
The age ranged 25-69 years. Elevated testosterone was observed in 4 patients. FIGO-stage: 14 were at Ia(10 moderately differentiated, 3 poorly differentiated, 5 retiform pattern).1 was at Ic. Patients with retiform pattern were more likely to exhibit endocrine function (p = 0.019, w = 0.61) and tumor diameter was significantly bigger in no endocrine function (p = 0.012, d = 1.52). All patients received surgical treatment. 8 received postoperative chemotherapy. The median follow-up was 66 months (20-112 months). 1 patient relapsed within 36 months and received cytoreductive surgery. She survived without disease after recurrence treatment. Of 5 patients who performed fertility sparing surgeries with the desire of childbirth, 3 had full-term pregnancy and 1 experienced a miscarriage. Another one has not tried to conceive.
The prognosis of SLCTs is good. Our data showed patients with retiform pattern were more likely to exhibit endocrine function. The diameter of tumor was significantly bigger in no endocrine function. Conservative surgery is the preferred option for patients with the desire of fertility at stage Ia. Postoperative chemotherapy is advised to cases with high-risk factors, but the most effective chemotherapy regimen is still uncertain.
由于支持细胞-间质细胞瘤（SLCT）的信息有限，本研究旨在描述 SLCT 的临床参数、治疗方法和治疗结果。
我们回顾性分析了 2009 年至 2020 年期间在青岛大学附属医院治疗的 15 例 SLCT 患者。研究了临床参数和治疗数据。
患者年龄为 25-69 岁，4 例患者出现睾酮升高。FIGO 分期：14 例为 Ia 期（10 例中分化，3 例低分化，5 例网状），1 例为 Ic 期。网状患者更可能表现出内分泌功能（p=0.019，w=0.61），且无内分泌功能的肿瘤直径更大（p=0.012，d=1.52）。所有患者均接受手术治疗，8 例术后接受化疗。中位随访时间为 66 个月（20-112 个月）。1 例患者在 36 个月内复发，接受了减瘤手术。复发治疗后，患者无病生存。在 5 例有生育要求并保留生育功能的患者中，3 例足月妊娠，1 例流产，1 例尚未尝试妊娠。
SLCT 的预后良好。我们的数据显示，网状患者更可能表现出内分泌功能，无内分泌功能的肿瘤直径更大。对于 Ia 期有生育要求的患者，保守手术是首选。对于有高危因素的病例，建议术后化疗，但最有效的化疗方案仍不确定。
