Zhang Chengcheng, Luo Zhenzhou, Wu Dingwei, Fei Jie, Xie Tianpei, Su Min
The Fourth Affiliated Hospital of Soochow University, Suzhou, 086-215000, China.
Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, 086- 350001, China.
Sci Rep. 2025 Apr 5;15(1):11709. doi: 10.1038/s41598-025-95896-w.
Lateral ankle sprains are one of the most common musculoskeletal injuries. Up to 70% of individuals who sustain lateral ankle sprains develop chronic ankle instability (CAI). Exercise therapy is considered an effective treatment for patients with CAI. This meta-analysis investigated the efficacy of exercise therapy in CAI patients by reviewing 15 randomized controlled trials (RCTs) involving 586 participants. Databases including PubMed, EMBASE, Cochrane Library, and Web of Science were searched from inception to September 13, 2024. The Cochrane Risk of Bias Tool was used to assess study quality. Meta-analysis, sensitivity analysis, and publication bias analysis were conducted using RevMan 5.3.0 and Stata 18.0 software. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was applied to evaluate the quality of evidence. Main outcomes were assessed using the Foot and Ankle Ability Measure (FAAM) and the Star Excursion Balance Test (SEBT). The results demonstrated that exercise therapy significantly improved FAAM-S (MD = 7.98, CI: 4.11 to 11.86, p < 0.0001, I² = 30%). Long-term exercise therapy (over 4 weeks) significantly enhanced FAAM-A (MD = 10.95, CI: 6.60 to 15.29, p < 0.00001, I² = 0%) and dynamic balance ability of ankle joint (SBET-A: MD = 4.83, CI: 1.04 to 8.63, p = 0.01, I² = 62%; SEBT-PM: MD = 6.93, CI: 2.37 to 11.48, p = 0.003, I² = 69%; and SEBT-PL: MD = 8.98, CI: 2.66 to 15.29, p = 0.005, I² = 86%). After categorizing by exercise type, the results indicated that strength training was more effective in improving SEBT-PL (MD = 8.15, CI: 6.09 to 10.21, p < 0.00001, I² = 0%), joint mobilization was more effective in improving SEBT-A (MD = 7.65, CI: 4.93 to 10.37, p < 0.00001, I² = 0%), and proprioceptive training was more effective in improving SEBT-PM (MD = 10.46, CI: 5.27 to 15.65, p < 0.0001, I² = 33%). In conclusion, long-term, multifaceted exercise therapy demonstrates superior rehabilitation efficacy for patients with CAI. Personalized treatment plans, informed by SEBT assessment results, should prioritize targeted interventions such as joint mobilization, strength training, or proprioceptive training. This approach holds significant theoretical and practical value for optimizing CAI treatment strategies and enhancing patient outcomes.
外侧踝关节扭伤是最常见的肌肉骨骼损伤之一。高达70%的外侧踝关节扭伤患者会发展为慢性踝关节不稳（CAI）。运动疗法被认为是治疗CAI患者的有效方法。本荟萃分析通过回顾15项涉及586名参与者的随机对照试验（RCT），研究了运动疗法对CAI患者的疗效。检索了包括PubMed、EMBASE、Cochrane图书馆和科学网在内的数据库，检索时间从建库至2024年9月13日。使用Cochrane偏倚风险工具评估研究质量。使用RevMan 5.3.0和Stata 18.0软件进行荟萃分析、敏感性分析和发表偏倚分析。应用推荐分级、评估、制定和评价（GRADE）方法评估证据质量。主要结局使用足踝能力量表（FAAM）和星形偏移平衡测试（SEBT）进行评估。结果表明，运动疗法显著改善了FAAM-S（MD = 7.98，CI：4.11至11.86，p < 0.0001，I² = 30%）。长期运动疗法（超过4周）显著提高了FAAM-A（MD = 10.95，CI：6.60至15.29，p < 0.00001，I² = 0%）以及踝关节的动态平衡能力（SBET-A：MD = 4.83，CI：1.04至8.63，p = 0.01，I² = 62%；SEBT-PM：MD = 6.93，CI：2.37至11.48，p = 0.003，I² = 69%；SEBT-PL：MD = 8.98，CI：2.66至15.29，p = 0.0
BMC Musculoskelet Disord. 2024-8-31
Clin Orthop Relat Res. 2020-2
J Bodyw Mov Ther. 2024-10
Sports (Basel). 2024-10-17
BMC Musculoskelet Disord. 2024-8-31
Int J Sports Phys Ther. 2023-6-1
Foot Ankle Clin. 2023-6
Zotero 插件
