Nishimura Ryosuke, Kanchanawong Pakorn
Mechanobiology Institute, National University of Singapore, Republic of Singapore.
Mechanobiology Institute, National University of Singapore, Republic of Singapore; Department of Biomedical Engineering, National University of Singapore, Republic of Singapore.
Curr Opin Cell Biol. 2025 Jun;94:102509. doi: 10.1016/j.ceb.2025.102509. Epub 2025 Apr 6.
Force generation and transmission in biological systems are driven by protein-based machinery organized at the nanoscale. Thus, technological advances that allow for the measurement or manipulation of molecular-scale features are key to new mechanobiological insights. Integrins, a superfamily of adhesion receptors, function by forming supramolecular complexes that mediate mechanobiological processes such as migration and matrix remodeling. This review highlights recent findings that harness advanced techniques in microscopy, nanotechnology, and biosensors to uncover nanoscale transformations that accompany integrin responses to mechanobiological stimuli. Recent discoveries are sharpening our understanding of the diverse functions and structural organization of different integrin heterodimers and their molecular partners, highlighting their critical roles in cellular processes.
生物系统中的力产生和传递由纳米级组织的基于蛋白质的机制驱动。因此，能够测量或操纵分子尺度特征的技术进步是获得新的力学生物学见解的关键。整合素是一类粘附受体超家族，通过形成介导迁移和基质重塑等力学生物学过程的超分子复合物发挥作用。本综述重点介绍了利用显微镜、纳米技术和生物传感器等先进技术的最新发现，以揭示整合素对力学生物学刺激作出反应时伴随的纳米级转变。最近的发现正在加深我们对不同整合素异二聚体及其分子伴侣的多种功能和结构组织的理解，突出了它们在细胞过程中的关键作用。
