Whipp Alyce M, Drouard Gabin, Rose Richard J, Pulkkinen Lea, Kaprio Jaakko
Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA.
Transl Psychiatry. 2025 Apr 6;15(1):128. doi: 10.1038/s41398-025-03362-y.
Despite increasing mental health problems among young people, few studies have examined associations between plasma proteins and mental health. Interactions between proteins and metabolites in association with mental health problems remain underexplored. In 730 twins, we quantified associations between plasma proteins measured at age 22 with 21 indicators of either depressive symptoms or the p-factor and tested for interactions with metabolites. Symptoms were collected from questionnaires and interviews completed by different raters (e.g., self-report, teachers) through adolescence to young adulthood (12 to 22 years). We found 47 proteins associated with depressive symptoms or the p-factor (FDR < 0.2), 9 being associated with both. Two proteins, contactin-1 and mast/stem cell growth factor receptor kit, positively interacted with valine levels in explaining p-factor variability. Our study demonstrates strong associations between plasma proteins and mental health and provides evidence for proteome-metabolome interactions in explaining higher levels of mental health problems.
尽管年轻人的心理健康问题日益增多，但很少有研究探讨血浆蛋白与心理健康之间的关联。蛋白质与代谢物之间与心理健康问题相关的相互作用仍未得到充分研究。在730对双胞胎中，我们量化了22岁时测量的血浆蛋白与21种抑郁症状指标或p因子之间的关联，并测试了与代谢物的相互作用。症状是通过不同评估者（如自我报告、教师）从青少年期到青年期（12至22岁）完成的问卷和访谈收集的。我们发现47种蛋白质与抑郁症状或p因子相关（FDR < 0.2），其中9种与两者都相关。两种蛋白质，接触蛋白-1和肥大/干细胞生长因子受体试剂盒，在解释p因子变异性时与缬氨酸水平呈正相互作用。我们的研究证明了血浆蛋白与心理健康之间的强烈关联，并为蛋白质组-代谢组相互作用在解释更高水平的心理健康问题方面提供了证据。
