Chen Wensheng, Xie Guojun, Xu Caixia, Liang Jiaquan, Zhang Chunguo
Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, 528000, Guangdong, China.
Sci Rep. 2025 Apr 7;15(1):11810. doi: 10.1038/s41598-025-96850-6.
Patients with depressive disorder with migraine (DDWM) are common, yet the neural mechanisms and brain function changes associated with this comorbidity remain partially understood. This study explores regional homogeneity (ReHo) abnormalities in resting-state functional magnetic resonance imaging (fMRI) and cognitive function in DDWM patients. We recruited 29 patients with DDWM, 34 patients with depressive disorder without migraine (DDWOM), and 43 matched healthy controls (HC). All participants underwent rs-fMRI scans, and imaging data were analyzed using ReHo. Cognitive function was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status. We also employed support vector machine (SVM) analysis to evaluate whether abnormal ReHo values could distinguish DDWM. he DDWM group exhibited significantly lower ReHo values in the left cuneus and left calcarine compared to the DDWOM group. ReHo values in these regions were negatively correlated with pain scores on the Visual Analogue Scale (r = - 0.3628, p = 0.0001; r = - 0.3142, p = 0.001) and positively correlated with the List_Recall score on RBANS (r = 0.260, p = 0.007). SVM analysis indicated that the left cuneus ReHo value could distinguish DDWM from DDWOM with 78.09% accuracy, 87.66% sensitivity, and 74.33% specificity. The left cuneus and left calcarine are potential biomarkers for migraine symptoms in DDWM, with the left cuneus affecting cognitive function related to memory.
患有偏头痛的抑郁症（DDWM）患者很常见，但与这种共病相关的神经机制和脑功能变化仍未完全明了。本研究探讨了DDWM患者静息态功能磁共振成像（fMRI）中的局部一致性（ReHo）异常和认知功能。我们招募了29例DDWM患者、34例无偏头痛的抑郁症（DDWOM）患者和43名匹配的健康对照（HC）。所有参与者均接受了静息态fMRI扫描，并使用ReHo分析成像数据。使用可重复神经心理状态评估量表评估认知功能。我们还采用支持向量机（SVM）分析来评估异常的ReHo值是否能够区分DDWM。与DDWOM组相比，DDWM组左侧楔叶和左侧距状裂的ReHo值显著降低。这些区域的ReHo值与视觉模拟量表上的疼痛评分呈负相关（r = -0.3628，p = 0.0001；r = -0.3142，p = 0.001），与RBANS上的List_Recall评分呈正相关（r = 0.260，p = 0.007）。SVM分析表明，左侧楔叶ReHo值能够以78.09%的准确率、87.66%的敏感度和74.33%的特异度区分DDWM和DDWOM。左侧楔叶和左侧距状裂是DDWM中偏头痛症状的潜在生物标志物，其中左侧楔叶影响与记忆相关的认知功能。
