Yao Xudong, Yin Zhiyang, Liu Fang, Wei Shengnan, Zhou Yifang, Jiang Xiaowei, Wei Yange, Xu Ke, Wang Fei, Tang Yanqing
Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; The 7th People's Hospital, Dalian, Liaoning, PR China.
Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
Neurosci Lett. 2018 Apr 23;673:28-32. doi: 10.1016/j.neulet.2018.02.033. Epub 2018 Feb 18.
Bipolar depression (BD) is easily misdiagnosed as unipolar depression (UD) or major depressive disorder (MDD) because the depressive symptoms can overlap. Regional homogeneity (ReHo), a measure commonly used for analyzing resting-state fMRI data, has been applied to the study of various neuropsychiatric disorders. However, to date, studies directly comparing BD and UD using ReHo have been relatively scarce. Further investigation is needed to study the latent pathophysiological mechanisms of BD and UD.
Fifty-five patients with BD and 76 patients with UD, as well as 113 healthy controls (HC), underwent resting-state functional magnetic resonance imaging (fMRI). We compared the voxel-wise ReHo across the whole brain for subjects in each of the three groups.
Significant differences were found in the left frontal cluster (LFC) across the three groups. There were differences between BD and UD in the LFC and left temporal cluster (LTC). In addition, differences between UD and HC existed in the LFC and the occipital cluster (OC). When comparing BD subjects with HC subjects, significant differences were found in all three clusters. No correlations were observed between the 17-item Hamilton Depression Rating Scale (HDRS-17) scores or sub-scores and the ReHo values of BD or UD patients.
ReHo values in the LFC differed significantly among BD, UD, and HC subjects. ReHo in the LTC showed significant differences between BD and UD that might serve as neuroimaging markers of BD. Further, BD and UD shared ReHo changes in the cuneus, suggesting that the cuneus might provide a depressive state neuroimaging marker of BD and UD patients.
双相抑郁症（BD）容易被误诊为单相抑郁症（UD）或重度抑郁症（MDD），因为其抑郁症状可能重叠。局部一致性（ReHo）是一种常用于分析静息态功能磁共振成像（fMRI）数据的指标，已被应用于各种神经精神疾病的研究。然而，迄今为止，使用ReHo直接比较BD和UD的研究相对较少。需要进一步研究以探讨BD和UD潜在的病理生理机制。
55例BD患者、76例UD患者以及113名健康对照者（HC）接受了静息态功能磁共振成像（fMRI）检查。我们比较了三组受试者全脑的体素水平ReHo。
三组在左侧额叶簇（LFC）存在显著差异。BD和UD在LFC以及左侧颞叶簇（LTC）存在差异。此外，UD和HC在LFC和枕叶簇（OC）存在差异。将BD受试者与HC受试者比较时，在所有三个簇中均发现显著差异。17项汉密尔顿抑郁量表（HDRS-17）评分或子评分与BD或UD患者的ReHo值之间未观察到相关性。
BD、UD和HC受试者的LFC中ReHo值存在显著差异。LTC中的ReHo在BD和UD之间显示出显著差异，这可能作为BD的神经影像学标志物。此外，BD和UD在楔叶的ReHo变化上有共同之处，表明楔叶可能为BD和UD患者提供一种抑郁状态神经影像学标志物。
