Wu Fujin, Wang Qing, Zheng Tongmei, Wang Xiuchun, Lin Chaobin
Department of Ophthalmology, Quanzhou First Hospital of Fujian Province, Quanzhou, 362000, Fujian, China.
Doc Ophthalmol. 2025 Apr;150(2):73-85. doi: 10.1007/s10633-025-10005-6. Epub 2025 Apr 7.
B-scan ultrasound is widely utilized for diagnosing posterior segment ocular disorders due to its non-invasive nature and ability to provide real-time imaging. This meta-analysis evaluates the diagnostic accuracy of B-scan ultrasound in detecting various posterior segment ocular disorders.
A comprehensive search was conducted across multiple databases including Medline, EMBASE, Cochrane Library, and SCOPUS, from their inception until May 2024. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was employed to assess the risk of bias in the included studies. A bivariate meta-analysis was performed to calculate pooled estimates of sensitivity, specificity, and other diagnostic performance measures. Statistical analyses were conducted using STATA 14.2, which included generating summary receiver operating characteristic curves and diagnostic odds ratios.
Ten studies met the inclusion criteria, encompassing a total of 1,617 reference-tested units. The pooled sensitivity and specificity of B-scan ultrasound for diagnosing posterior segment ocular disorders were remarkably high at 96% (95% CI 91-98%) and 94% (95% CI 87-98%), respectively. The diagnostic odds ratio was 363 (95% CI 94-1406), indicating substantial diagnostic accuracy. The area under the curve (AUC) was 0.99, confirming the excellent capability of B-scan ultrasound. Notable heterogeneity was observed (I = 86%), and no significant publication bias was detected.
B-scan ultrasound demonstrates high sensitivity and specificity in diagnosing posterior segment ocular disorders, confirming its utility as a reliable diagnostic tool in clinical practice.
B 超因其无创性和提供实时成像的能力而被广泛用于诊断眼后段疾病。本荟萃分析评估 B 超在检测各种眼后段疾病中的诊断准确性。
对多个数据库进行全面检索，包括 Medline、EMBASE、Cochrane 图书馆和 SCOPUS，检索时间从各数据库建库至 2024 年 5 月。采用诊断准确性研究质量评估工具 2（QUADAS - 2）评估纳入研究的偏倚风险。进行双变量荟萃分析以计算敏感性、特异性和其他诊断性能指标的合并估计值。使用 STATA 14.2 进行统计分析，包括生成汇总受试者工作特征曲线和诊断比值比。
十项研究符合纳入标准，共涉及 1617 个参考检测单位。B 超诊断眼后段疾病的合并敏感性和特异性分别高达 96%（95%可信区间 91 - 98%）和 94%（95%可信区间 87 - 98%）。诊断比值比为 363（95%可信区间 94 - 1406），表明诊断准确性高。曲线下面积（AUC）为 0.99，证实了 B 超的卓越性能。观察到显著的异质性（I = 86%），未检测到明显的发表偏倚。
B 超在诊断眼后段疾病方面表现出高敏感性和特异性，证实其在临床实践中作为可靠诊断工具的实用性。
