Russell Jason K, Conley Alexander C, Boyd Brian D, Begnoche John Patrick, Schlossberg Rachel, Stranick Allison, Rosenberg Adam J, Acosta Lealani Mae Y, Martin Dann, Neal Yasmeen, Rafii Michael S, Dumas Julie, Newhouse Paul A
Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alzheimers Dement. 2025 Apr;21(4):e70134. doi: 10.1002/alz.70134.
Adults with Down syndrome (DS) have increased risk of Alzheimer's disease (AD). The cholinergic system declines in AD, underlying many cognitive deficits. We investigated the relationship between amyloid accumulation and cholinergic terminal density in adults with DS compared to amyloid-matched controls.
A total of 15 non-demented adults with DS and 15 amyloid-matched healthy controls were assessed for [F]-FEOBV uptake differences and [F]-FEOBV uptake relationships with amyloid accumulation and cognitive performance.
Adults with DS displayed greater [F]-FEOBV uptake than controls, with a similar uptake pattern. Amyloid-associated differences in [F]-FEOBV uptake were observed in adults with DS. [F]-FEOBV uptake in adults with DS was positively associated with cognition.
Adults with DS display higher [F]-FEOBV uptake than amyloid-matched controls but relatively lower [F]-FEOBV uptake in individuals with elevated amyloid. Thus, the cholinergic system appears to be adversely affected by AD pathology in individuals with DS, which may be relevant to cognitive decline.
Adults with DS display greater cholinergic terminal density in specific ROIs than amyloid-match controls. Adults with DS exhibit a similar pattern of cholinergic terminal density across the brain. The first association of cholinergic terminal density with AD pathology in non-demented adults with DS. Adults with DS display a greater cholinergic terminal decline in association with amyloid accumulation than neurotypically developed age-matched controls. Region-specific cholinergic terminal density associated with cognitive performance in adults with DS.
患有唐氏综合征（DS）的成年人患阿尔茨海默病（AD）的风险增加。AD患者的胆碱能系统会衰退，这是许多认知缺陷的潜在原因。我们研究了与淀粉样蛋白匹配的对照组相比，DS成年人中淀粉样蛋白积累与胆碱能终末密度之间的关系。
对15名非痴呆的DS成年人和15名淀粉样蛋白匹配的健康对照者进行了评估，以检测[F]-FEOBV摄取差异以及[F]-FEOBV摄取与淀粉样蛋白积累和认知表现之间的关系。
DS成年人的[F]-FEOBV摄取高于对照组，且摄取模式相似。在DS成年人中观察到了与淀粉样蛋白相关的[F]-FEOBV摄取差异。DS成年人的[F]-FEOBV摄取与认知呈正相关。
DS成年人的[F]-FEOBV摄取高于淀粉样蛋白匹配的对照组，但在淀粉样蛋白水平升高的个体中[F]-FEOBV摄取相对较低。因此，胆碱能系统在DS个体中似乎受到AD病理的不利影响，这可能与认知衰退有关。
与淀粉样蛋白匹配的对照组相比，DS成年人在特定脑区显示出更高的胆碱能终末密度。DS成年人在整个大脑中表现出相似的胆碱能终末密度模式。这是首次在非痴呆的DS成年人中发现胆碱能终末密度与AD病理之间的关联。与神经典型发育的年龄匹配对照组相比，DS成年人与淀粉样蛋白积累相关的胆碱能终末衰退更大。DS成年人中与认知表现相关的区域特异性胆碱能终末密度。
