肠道微生物群及其代谢产物：糖尿病肾病的隐藏驱动因素？揭示肠道微生物在糖尿病肾病中的作用。
Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN.
作者信息
Liu Jinzhou, Guo Min, Yuan Xiaobin, Fan Xiao, Wang Jin, Jiao Xiangying
机构信息
Department of Physiology, The Key Laboratory of Physiology of Shanxi Province, the Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, China.
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, China.
出版信息
J Diabetes. 2025 Apr;17(4):e70068. doi: 10.1111/1753-0407.70068.
BACKGROUND
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis.
METHODS
Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development.
RESULTS
Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways.
CONCLUSIONS
Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities.
背景
糖尿病肾病（DN）是糖尿病严重的微血管并发症，其发病机制复杂。
方法
回顾近期研究以探讨肠道微生物群及其代谢产物在DN发生发展中的作用。
结果
肠道细菌失调会导致肾小球硬化和肾小管损伤等病理变化。微生物代谢产物通过免疫和炎症途径参与DN的发生。
结论
了解肠道微生物群及其代谢产物与DN之间的关系可能为DN的诊断、预防和治疗提供潜在启示。将这一知识转化为临床实践既存在挑战也带来机遇。
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