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针对唐氏综合征幼儿的执行功能干预的可行性和初步疗效

Feasibility and Preliminary Efficacy of an Executive Function Intervention for Young Children With Down Syndrome.

作者信息

Pinks Miranda E, Walsh Madison M, Colaianni Sara, Onnivello Sara, Marcolin Chiara, Looney Sarah, Rossi Elisa, Pulina Francesca, Prince Mark A, Riggs Nathaniel R, Hepburn Susan, Daunhauer Lisa A, Kaylyn Van Deusen, Lanfranchi Silvia, Fidler Deborah J

机构信息

Colorado State University, Fort Collins, Colorado, USA.

University of Padua, Padua, Italy.

出版信息

J Intellect Disabil Res. 2025 Jul;69(7):546-557. doi: 10.1111/jir.13234. Epub 2025 Apr 6.

Abstract

BACKGROUND

Individuals with Down syndrome (DS) have an elevated likelihood of challenges with executive function (EF) throughout the lifespan, and syndrome-informed intervention approaches that strengthen these foundations during early childhood may be beneficial. This single group baseline versus postintervention pilot study presents findings from the implementation of a syndrome-informed, parent-mediated intervention designed to support the development of EF in preschool-aged children with DS (EXPO: Executive Function Play Opportunities).

METHOD

Participants were 34 children aged 3-7 years old with DS and their caregivers. The full sample participated in a novel 12-week parent-mediated intervention focused on building working memory, inhibitory control, cognitive flexibility and planning skills. Participants were evaluated at baseline and poststudy for feasibility outcomes and preliminary evidence of intervention efficacy.

RESULTS

Activities were feasible for families to implement and appropriate for the developmental range of participants in the study. Preliminary evidence of efficacy was observed via laboratory-based EF outcome measures. Within-sample heterogeneity in response to intervention was also observed.

CONCLUSIONS

EXPO is feasible for a larger trial in its current form. Additional intervention modifications may further increase the potential impact of EXPO by addressing heterogeneity in presentations among young children with DS.

摘要

背景

唐氏综合征(DS)患者在其一生中执行功能(EF)出现问题的可能性较高,而在幼儿期强化这些基础的综合征知情干预方法可能有益。这项单组基线与干预后试点研究展示了一项综合征知情、家长介导干预措施的实施结果,该干预旨在支持患有DS的学龄前儿童的执行功能发展(EXPO:执行功能游戏机会)。

方法

参与者为34名3至7岁患有DS的儿童及其照顾者。整个样本参与了一项为期12周的新型家长介导干预,重点是培养工作记忆、抑制控制、认知灵活性和计划技能。在基线和研究结束时对参与者进行评估,以获取可行性结果和干预效果的初步证据。

结果

这些活动对家庭来说实施起来是可行的,并且适合研究中参与者的发育范围。通过基于实验室的执行功能结果测量观察到了疗效的初步证据。还观察到样本内对干预反应的异质性。

结论

EXPO以其目前的形式进行更大规模试验是可行的。通过解决患有DS的幼儿表现的异质性,进一步的干预调整可能会进一步增加EXPO的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcf/12198097/16e9b859760c/JIR-69-546-g003.jpg

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