Luthfiyah Sari, Lawang Wannarat, Shifaza Fathimath
Department of Nursing, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia.
Faculty of Nursing, Burapha University, Chon Buri, Thailand.
Nutr Metab Cardiovasc Dis. 2025 Jun;35(6):103977. doi: 10.1016/j.numecd.2025.103977. Epub 2025 Mar 8.
This study investigates the causal relationships between cardiovascular risk factors, such as smoking, alcohol consumption, and obesity, and their association with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) through Mendelian randomization analysis. The results indicate that smoking and obesity are causally linked to an increased risk of DCM, while alcohol consumption and other examined factors did not show significant causal relationships. The study uses a robust Mendelian randomization methodology to minimize biases common in traditional observational research, although the dataset's limited genetic diversity (derived from individuals of European ancestry) and the potential for confounding remain as limitations. This research highlights the importance of smoking cessation and weight management in the prevention of DCM and provides valuable insights into the genetic and lifestyle determinants of cardiomyopathies.
本研究通过孟德尔随机化分析，调查心血管危险因素（如吸烟、饮酒和肥胖）之间的因果关系，以及它们与扩张型心肌病（DCM）和肥厚型心肌病（HCM）的关联。结果表明，吸烟和肥胖与DCM风险增加存在因果联系，而饮酒和其他检测因素未显示出显著的因果关系。该研究采用了稳健的孟德尔随机化方法，以尽量减少传统观察性研究中常见的偏差，尽管数据集有限的遗传多样性（源自欧洲血统个体）和潜在的混杂因素仍是局限性。这项研究强调了戒烟和体重管理在预防DCM中的重要性，并为心肌病的遗传和生活方式决定因素提供了有价值的见解。
