• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
K1.1 channels in cardiorespiratory regulation and sudden unexpected death in epilepsy: insights from mouse models.K1.1通道在心肺调节及癫痫性意外猝死中的作用：来自小鼠模型的见解
Brain Commun. 2025 Mar 20;7(2):fcaf116. doi: 10.1093/braincomms/fcaf116. eCollection 2025.
2
New inroads into the brain circuits and network dynamics behind sudden unexpected death in epilepsy.对癫痫性猝死背后的脑回路和网络动力学的新突破。
Brain Commun. 2022 Apr 13;4(2):fcac097. doi: 10.1093/braincomms/fcac097. eCollection 2022.
3
Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.皮质边缘回路中靶向性Kv1.1缺乏的小鼠的癫痫发作和过早死亡
Brain Commun. 2025 Jan 16;7(1):fcae444. doi: 10.1093/braincomms/fcae444. eCollection 2025.
4
Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation.神经元特异性 Kv1.1 缺乏足以导致癫痫、早逝和心肺功能失调。
Neurobiol Dis. 2020 Apr;137:104759. doi: 10.1016/j.nbd.2020.104759. Epub 2020 Jan 21.
5
Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy.癫痫 Kv1.1 敲除小鼠（一种癫痫猝死的模型）的猝死之前存在休息不足的蓄积。
Epilepsia. 2018 Jan;59(1):92-105. doi: 10.1111/epi.13953. Epub 2017 Nov 28.
6
Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy.心肺功能分析揭示 Kcna1 基因敲除小鼠的原发性呼吸功能障碍：对癫痫猝死的影响。
Neurobiol Dis. 2019 Jul;127:502-511. doi: 10.1016/j.nbd.2019.04.006. Epub 2019 Apr 8.
7
Spontaneous seizures in Kcna1-null mice lacking voltage-gated Kv1.1 channels activate Fos expression in select limbic circuits.缺乏电压门控Kv1.1通道的Kcna1基因敲除小鼠的自发性癫痫发作会激活特定边缘回路中的Fos表达。
J Neurochem. 2015 Oct;135(1):157-64. doi: 10.1111/jnc.13206. Epub 2015 Jul 14.
8
Kv1.1 subunits localize to cardiorespiratory brain networks in mice where their absence induces astrogliosis and microgliosis.Kv1.1 亚基定位于小鼠的心肺呼吸脑网络中，其缺失会诱导星形胶质细胞增生和小胶质细胞增生。
Mol Cell Neurosci. 2021 Jun;113:103615. doi: 10.1016/j.mcn.2021.103615. Epub 2021 Apr 24.
9
The Kv1.1 null mouse, a model of sudden unexpected death in epilepsy (SUDEP).Kv1.1 基因敲除小鼠，癫痫猝死（SUDEP）模型。
Epilepsia. 2014 Nov;55(11):1808-16. doi: 10.1111/epi.12793. Epub 2014 Nov 6.
10
Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.Kv1.1 钾通道缺陷揭示了脑驱动的心脏功能障碍作为癫痫性不明原因猝死的候选机制。
J Neurosci. 2010 Apr 14;30(15):5167-75. doi: 10.1523/JNEUROSCI.5591-09.2010.

本文引用的文献

1
Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.皮质边缘回路中靶向性Kv1.1缺乏的小鼠的癫痫发作和过早死亡
Brain Commun. 2025 Jan 16;7(1):fcae444. doi: 10.1093/braincomms/fcae444. eCollection 2025.
2
Loss-of-function variants in K 11.1 cardiac channels as a biomarker for SUDEP.K 11.1 心脏通道功能丧失变异作为 SUDEP 的生物标志物。
Ann Clin Transl Neurol. 2021 Jul;8(7):1422-1432. doi: 10.1002/acn3.51381. Epub 2021 May 18.
3
Are Variants Causing Cardiac Arrhythmia Risk Factors in Sudden Unexpected Death in Epilepsy?导致癫痫猝死中心律失常风险因素的变异体？
Front Neurol. 2020 Sep 8;11:925. doi: 10.3389/fneur.2020.00925. eCollection 2020.
4
Kv1.1 Channelopathies: Pathophysiological Mechanisms and Therapeutic Approaches.Kv1.1 通道病：病理生理机制和治疗方法。
Int J Mol Sci. 2020 Apr 22;21(8):2935. doi: 10.3390/ijms21082935.
5
Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation.神经元特异性 Kv1.1 缺乏足以导致癫痫、早逝和心肺功能失调。
Neurobiol Dis. 2020 Apr;137:104759. doi: 10.1016/j.nbd.2020.104759. Epub 2020 Jan 21.
6
Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy.心肺功能分析揭示 Kcna1 基因敲除小鼠的原发性呼吸功能障碍：对癫痫猝死的影响。
Neurobiol Dis. 2019 Jul;127:502-511. doi: 10.1016/j.nbd.2019.04.006. Epub 2019 Apr 8.
7
Genetic Basis of Sudden Unexpected Death in Epilepsy.癫痫性猝死的遗传基础
Front Neurol. 2017 Jul 20;8:348. doi: 10.3389/fneur.2017.00348. eCollection 2017.
8
Acute Symptomatic Seizures Caused by Electrolyte Disturbances.电解质紊乱引起的急性症状性癫痫发作
J Clin Neurol. 2016 Jan;12(1):21-33. doi: 10.3988/jcn.2016.12.1.21.
9
Exome-based analysis of cardiac arrhythmia, respiratory control, and epilepsy genes in sudden unexpected death in epilepsy.基于外显子组的分析，在癫痫性猝死中，心脏心律失常、呼吸控制和癫痫基因。
Ann Neurol. 2016 Apr;79(4):522-34. doi: 10.1002/ana.24596. Epub 2016 Feb 2.
10
Recognizing and preventing epilepsy-related mortality: A call for action.认识并预防与癫痫相关的死亡：行动呼吁。
Neurology. 2016 Feb 23;86(8):779-86. doi: 10.1212/WNL.0000000000002253. Epub 2015 Dec 16.

K1.1通道在心肺调节及癫痫性意外猝死中的作用：来自小鼠模型的见解

K1.1 channels in cardiorespiratory regulation and sudden unexpected death in epilepsy: insights from mouse models.

作者信息

Hu Amanda, Aung Khaing Phyu, Reid Christopher A, Soh Ming S

机构信息

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.

出版信息

Brain Commun. 2025 Mar 20;7(2):fcaf116. doi: 10.1093/braincomms/fcaf116. eCollection 2025.

DOI:10.1093/braincomms/fcaf116
PMID:40190353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11969661/
Abstract

This scientific commentary refers to 'Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits', by Paulhus and Glasscock (https://doi.org/10.1093/braincomms/fcae444).

摘要

本科学评论参考了保罗胡斯和格拉斯考克所著的《皮质边缘回路中靶向Kv1.1缺乏小鼠的癫痫发作和过早死亡》（https://doi.org/10.1093/braincomms/fcae444）。