Amisu Mumuni, Chionuma Joy, Odeyemi Ayoola, Odetayo Odewale
Lagos State University College of Medicine, Medicine.
Lagos State University College of Medicine, Obstetrics and Gynaecology.
Afr Health Sci. 2024 Dec;24(4):156-162. doi: 10.4314/ahs.v24i4.21.
Symptomatic uterine fibroids causing obstructive nephropathy were thought to be uncommon, but recent prevalence studies showed otherwise. The aim of the study is to determine the prevalence of obstructive uropathy and nephropathy in patients with uterine leiomyoma.
The study was a hospital-based cross-sectional retrospective study of 114 patients diagnosed with symptomatic uterine fibroids seen in the gynecology clinic of Lagos State University Teaching Hospital, Ikeja from February 2021 to June 2022.
The overall prevalence of obstructive uropathy and nephropathy was 22.8% and 10.5% respectively. The average level of serum creatinine was 2.2 ± 1.9mg/dl with a creatinine range of 1.8 to 6.7mg dl. The average of the GFR among patients was 29.3 ± 13.4ml/min/1.73m with a range of 9 - 54ml/min/1.73m. There is a positive association between uterine size and uropathy and subjects with uropathy are more likely to develop nephropathy. (CI 95% 3.281 - 108.670).
This study showed that prevalence of obstructive nephropathy in the patients with uterine leiomyomata is 10.5%. Uterine size and myoma diameter were positively associated with development of obstructive nephropathy.
有症状的子宫肌瘤导致梗阻性肾病曾被认为不常见，但近期的患病率研究结果却并非如此。本研究的目的是确定子宫肌瘤患者中梗阻性尿路病和肾病的患病率。
本研究是一项基于医院的横断面回顾性研究，研究对象为2021年2月至2022年6月在伊凯贾拉各斯州立大学教学医院妇科门诊确诊为有症状子宫肌瘤的114例患者。
梗阻性尿路病和肾病的总体患病率分别为22.8%和10.5%。血清肌酐平均水平为2.2±1.9mg/dl，肌酐范围为1.8至6.7mg/dl。患者的肾小球滤过率平均为29.3±13.4ml/min/1.73m²，范围为9至54ml/min/1.73m²。子宫大小与尿路病之间存在正相关，且患有尿路病的患者更易发生肾病。（95%置信区间3.281 - 108.670）
本研究表明，子宫肌瘤患者中梗阻性肾病的患病率为10.5%。子宫大小和肌瘤直径与梗阻性肾病的发生呈正相关。
