Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria.
Department of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.
Biol Trace Elem Res. 2024 Jun;202(6):2501-2508. doi: 10.1007/s12011-023-03873-z. Epub 2023 Sep 27.
Studies have suggested the potential roles of serum macronutrients such as calcium and magnesium in the development of uterine fibroids. The primary objective was to assess the association between serum magnesium and calcium levels and the prevalence of uterine fibroids in women of reproductive age. A cross-sectional study of 194 parity-matched women with or without a sonographic diagnosis of uterine fibroids enrolled at a university teaching hospital in Lagos, Southwest Nigeria. Participants' sociodemographic, ultrasound, and anthropometric information as well as the estimated serum levels of calcium and magnesium were collected for statistical analyses. This study found significant negative associations between low serum calcium levels and uterine fibroids (adjusted odds ratio = 0.06), uterine size, and the number of fibroid nodules. However, no significant association was observed between serum magnesium levels and uterine fibroids. This study found significant inverse associations between low serum calcium levels and uterine fibroids, uterine size, and the number of fibroid nodules.
研究表明，血清宏量营养素（如钙和镁）在子宫肌瘤的发生发展中可能发挥作用。本研究旨在评估血清镁和钙水平与育龄期妇女子宫肌瘤患病率之间的关系。这是一项在尼日利亚西南部拉各斯一所大学教学医院进行的横断面研究，共纳入了 194 名经超声诊断患有或未患有子宫肌瘤的经产匹配妇女。收集了参与者的社会人口学、超声和人体测量学信息以及估计的血清钙和镁水平，以进行统计分析。本研究发现，低血清钙水平与子宫肌瘤（校正优势比=0.06）、子宫大小和肌瘤结节数量之间存在显著负相关。然而，血清镁水平与子宫肌瘤之间无显著相关性。本研究发现，低血清钙水平与子宫肌瘤、子宫大小和肌瘤结节数量之间存在显著的负相关。
