Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Department of Obstetrics and Gynecology, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Mol Neurobiol. 2023 Jul;60(7):3569-3583. doi: 10.1007/s12035-023-03271-5. Epub 2023 Feb 25.
miR-124 is a miRNA predominantly expressed in the nervous system and accounts for more than a quarter of the total miRNAs in the brain. It regulates neurogenesis, neuronal differentiation, neuronal maturation, and synapse formation and is the most important miRNA in the brain. Furthermore, emerging evidence has suggested miR-124 may be associated with the pathogenesis of various neurodevelopmental and neuropsychiatric disorders. Here, we provide an overview of the role of miR-124 in neurodevelopment and the underling mechanisms, and finally, we prospect the significance of miR-124 research to the field of neuroscience.
miR-124 是一种主要在神经系统中表达的 miRNA，占大脑中总 miRNA 的四分之一以上。它调节神经发生、神经元分化、神经元成熟和突触形成，是大脑中最重要的 miRNA。此外，新出现的证据表明，miR-124 可能与各种神经发育和神经精神疾病的发病机制有关。在这里，我们概述了 miR-124 在神经发育中的作用及其潜在机制，最后展望了 miR-124 研究对神经科学领域的意义。
